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鲍丙豪,王彬,王继升,代恒恒,邓省,冯隽龙,李海松.基于数据挖掘的中医药治疗少弱精子症用药规律分析[J].湖南中医药大学学报,2020,40(11):1366-1370[点击复制] |
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| 基于数据挖掘的中医药治疗少弱精子症用药规律分析 |
| 鲍丙豪,王彬,王继升,代恒恒,邓省,冯隽龙,李海松 |
| (北京中医药大学东直门医院, 北京 100700;北京中医药大学研究生院, 北京 100029) |
| 摘要: |
| 目的 基于数据挖掘方法分析中医药方剂治疗少弱精子症的组方用药规律。方法 收集中国知网（CNKI）中近10年来中医药治疗少弱精子症的文献，并将其作为数据源，通过筛选后建立方剂数据库，在“中医传承辅助系统（V2.5）”的帮助下进行数据分析与挖掘，对中医证候分布，用药频次，四气、五味、归经分布，用药模式和新处方等进行总结研究。结果 共纳入169篇文献中合格处方185首，涉及135味中药；主要中医证候分布为肾精不足、肝肾亏虚、脾胃气虚、瘀血阻滞、湿热下注；使用频次在前6位的药物分别是菟丝子、枸杞子、熟地黄、淫羊藿、黄芪、当归；所用药性以温性居多，药味以甘、辛、苦、酸为主，归经主入肾、脾、肝三经；菟丝子-枸杞子药物组合出现频次最高，置信度较高的关联规则有“车前子，枸杞子→菟丝子”“枸杞子，覆盆子→菟丝子”；新候选处方多以五子衍宗丸、六味地黄丸等经典名方为基础。结论 目前中医药在辨证治疗少弱精子症中以填精为主，补肾的同时兼顾脾胃，以补肾健脾、疏肝活血为主要治法。 |
| 关键词: 少弱精子症 男性不育 数据挖掘 中医传承辅助系统 用药规律 |
| DOI：10.3969/j.issn.1674-070X.2020.11.014 |
| 投稿时间：2020-01-05 |
| 基金项目:国家自然科学基金面上项目（81774320）；北京中医药薪火传承“3+3”工程（2016-SZ-C-60）。 |
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| Analysis of Medication Rules of Traditional Chinese Medicine in the Treatment of Oligozoospermia Based on Data Mining |
| BAO Binghao,WANG Bin,WANG Jisheng,DAI Hengheng,DENG Sheng,FENG Junlong,LI Haisong |
| (Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China;Graduate School of Beijing University of Chinese Medicine, Beijing 100029, China) |
| Abstract: |
| Objective To analyze the prescription and medication rule of traditional Chinese medicine (TCM) prescription in treating oligoasthenospermia based on the data mining method. Methods The literatures on the treatment of oligoasthenospermia with traditional Chinese medicine in the Chinese Journal Full-text Database (CNKI) in the past 10 years were collected and used as a data source. After screening, a prescription database was established. With the help of the "Traditional Chinese Medicine Inheritance Assistant System (V2.5)", data analysis and mining were performed. The distribution of TCM syndromes, frequency of medication, the distribution of four Qi, five flavors, and channel tropism, medication mode and new prescriptions were summarized and studied. Results A total of 185 qualified prescriptions from 169 papers were included, involving 135 Chinese materia medica. The main distribution of TCM syndromes were insufficient kidney essence, liver kidney deficiency, spleen stomach Qi deficiency, blood stasis stagnation, dampness-heat diffusing downward. The top 6 herbs of frequency were Semen Cuscutae, Fructus Lycii, Radix Rehmanniae Preparata, Herba Epimedii, Radix Astragali seu Hedysari, Radix Angelicae Sinensis. The nature of herbs were mainly warm, and flavors were mainly sweet, pungent, bitter, sour. Channel tropism was mainly the liver, kidney, spleen. The herb pair of Semen Cuscutae and Fructus Lycii was mostly frequent used. The higher degree of confidence of association rules were "Semen Plantaginis, Fructus Lycii→Semen Cuscutae", "Fructus Lycii, Fructus Rubi→Semen Cuscutae". New candidate prescriptions were mainly based on Wuzi Yanzong Pills, Liuwei Dihuang Pills, and other classic famous prescriptions. Conclusion Traditional Chinese medicine in the treatment of oligoasthenospermia with syndrome differentiation is mainly to replenish essence. Consideration is given to spleen and stomach when tonifying the kidney. The main treatment method is tonifying the kidney, invigorating the liver, soothing the liver and activating blood circulation. |
| Key words: oligoasthenospermia data mining male infertility Traditional Chinese Medicine Inheritance Assistant System medication rule |
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