| 引用本文: |
周亮,范洪桥,王月,葛安琪,李松莲,罗君.基于数据挖掘分析刘丽芳教授治疗浆细胞性乳腺炎的用药规律[J].湖南中医药大学学报,2020,40(5):587-591[点击复制] |
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| 基于数据挖掘分析刘丽芳教授治疗浆细胞性乳腺炎的用药规律 |
| 周亮,范洪桥,王月,葛安琪,李松莲,罗君 |
| (湖南中医药大学第一附医院乳腺科, 湖南 长沙 410007) |
| 摘要: |
| 目的 分析刘丽芳教授治疗浆细胞性乳腺炎的用药特点及治疗规律，为临床治疗提供参考。方法 追踪与整理刘教授2013年1月-2018年1月于湖南中医药大学第一附属医院乳腺科门诊治疗的浆细胞性乳腺炎有效医案。将收集到的有效医案按肿块期、脓肿期、瘘管期进行分类，将筛选后的数据录入软件，建立方药数据库。运用数据挖掘软件对浆细胞性乳腺炎的处方用药进行大数据分析，证、法、方、药进行关联规则挖掘，并结合中医药理论对统计结果进行分析。结果 肿块期核心处方：蒲公英-金银花-土贝母-醋鳖甲-连翘-柴胡-海藻-炒芥子-白术；脓肿期核心处方：蒲公英-金银花-白术-皂角刺-连翘-土贝母-黄芪-炒麦芽；瘘管期核心处方：蒲公英-金银花-连翘-黄芪-皂角刺-土贝母-白术-醋鳖甲-炒芥子等。结论 肿块期高频药物以清、散+温为主，补益类药物用量很少；脓肿期以清、散+补为主，温阳类药物用量很少；瘘管期以清、散+补益类少佐温阳类药物。三个阶段用药各具特色，总体以“清热解毒、活血化痰散结”为主，兼以“温化、补益”为其主要用药特点。 |
| 关键词: 浆细胞性乳腺炎 刘丽芳 用药规律 数据挖掘 |
| DOI：10.3969/j.issn.1674-070X.2020.05.015 |
| 投稿时间：2019-05-29 |
| 基金项目:湖南省中医药科研计划项目（201829）。 |
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| Study on Medication Rule of Professor LIU Lifang in the Treatment of Plasma Cell Mastitis Based on Data Mining |
| ZHOU Liang,FAN Hongqiao,WANG Yue,GE Anqi,LI Songlian,LUO Jun |
| (Galactophore Department, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To analyze the medication characteristics and treatment rules of Professor LIU Lifang in treating plasma cell mastitis, so as to provide references for clinical treatment. Methods The effective medical records of plasma cell mastitis treated by Professor LIU in the outpatient of Galactophore Department, The First Affiliated Hospital of Hunan University of Chinese Medicine from January 2013 to January 2018 were collected. The collected medical records were classified according to the stage of mass, abscess and fistula. The screened data were input into software and the prescription database was established. The data mining software was used to analyze the large data of the prescription medication of plasma cell mastitis. Syndrome, method, prescription and medicine were mining association rules, and the statistical mining results were analyzed combined with the theory of traditional Chinese medicine (TCM). Results Core prescriptions of mass stage were Herba Taraxaci-Flos Lonicerae-Rhizoma Bolbostemmatis-vinegar processed Carapax Trionycis-Fructus Forsythiae-Radix Bupleuri-Sargassum-fried Semen Sinapis Albae-Rhizoma Atractylodis Macrocephalae; Core prescriptions of abscess stage were Herba Taraxaci-Flos Lonicerae-Rhizoma Atractylodis Macrocephalae-Spina Gleditsiae-Fructus Forsythiae-Rhizoma Bolbostemmatis-Radix Astragali seu Hedysari-fried Fructus Hordei Germinatus; Core prescriptions of fistula stage were Herba Taraxaci-Flos Lonicerae-Fructus Forsythiae-Radix Astragali seu Hedysari-Spina Gleditsiae-Rhizoma Bolbostemmatis-Rhizoma Atractylodis Macrocephalae-vinegar processed Carapax Trionycis-fried Semen Sinapis Albae. Conclusion Medicine of clearing, dissipating, warming are the main high-frequency drugs in the stage of mass, and the dosage of tonic drugs is very small. Qing, Medicine of dissipating and tonifying are the main drugs in the stage of abscess, while the dosage of warming Yang drugs is very small. In the stage of fistula, medicine of clearing, dissipating and tonifying are used to assist warming Yang drugs. The medicines of three stages have their own characteristics. Generally, they are mainly characterized by "clearing away heat and detoxification, activating blood circulation, resolving phlegm and resolving mass", as well as "warming and resolving, tonifying". |
| Key words: plasma cell mastitis LIU Lifang medication rule data mining |
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