| 引用本文: |
覃艮艳,蒋鹏飞,彭俊,陈立浩,黎冬冬,李洁,彭清华.普拉洛芬联合玻璃酸钠治疗干眼的临床观察[J].湖南中医药大学学报,2020,40(4):490-493[点击复制] |
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| 普拉洛芬联合玻璃酸钠治疗干眼的临床观察 |
| 覃艮艳,蒋鹏飞,彭俊,陈立浩,黎冬冬,李洁,彭清华 |
| (湖南中医药大学, 湖南 长沙 410208;湖南中医药大学第一附属医院, 湖南 长沙 410007;湖南中医药大学, 湖南 长沙 410208;中医药防治眼耳鼻咽喉疾病湖南省重点实验室, 湖南 长沙 410208) |
| 摘要: |
| 目的 对普拉洛芬联合玻璃酸钠与单纯使用玻璃酸钠治疗干眼进行临床观察。方法 将180例干眼患者随机分为观察组与对照组，观察组采用普拉洛芬联合玻璃酸钠治疗，对照组采用单纯玻璃酸钠治疗，通过比较两组患者治疗前后的泪膜破裂时间、泪液分泌试验、角膜荧光素染色评分、干眼症状评分的变化，观察两种治疗方法的临床疗效。结果 两组治疗的临床有效率分别为95.56%和83.33%，观察组临床有效率优于对照组（P<0.05）；治疗后2周、4周两组泪液分泌试验、泪膜破裂时间比较，观察组均高于对照组，差异有统计学意义（P<0.05）；治疗后2周、4周两组干眼症状评分、角膜荧光素染色评分比较，观察组均低于对照组，差异有统计学意义（P<0.05）。结论 对于干眼患者，从临床有效率、干眼症状评分、泪液分泌试验、泪膜破裂时间及角膜荧光素染色评分等方面分析，普拉洛芬联合玻璃酸钠组治疗方案优于单纯使用玻璃酸钠，值得临床推广应用。 |
| 关键词: 普拉洛芬 玻璃酸钠 干眼 泪膜破裂时间 泪液分泌试验 角膜荧光素染色评分 干眼症状评分 |
| DOI：10.3969/j.issn.1674-070X.2020.04.021 |
| 投稿时间：2018-09-07 |
| 基金项目:国家自然科学基金面上项目资助（30772824、81574031）；中央财政支持地方高校资助项目；国家中医药管理局中医眼科学重点学科建设项目；湖南省高层次卫生人才“225”工程培养对象项目资助；湖南省科技厅科研基金资助项目（2015SF2016-6）；湖南省发展和改革委员会科研基金资助项目（湘发改投资〔2014〕658号）；湖南省中医五官科学重点学科建设项目；湖南省中医药防治眼耳鼻咽喉疾病与视功能保护工程技术研究中心资助项目；湖南省研究生科研创新课题资助（CX2018B497）；长沙市科技计划重大专项资助（K1501014-31）。 |
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| Clinical Observation on Praloprofen Combined with Sodium Hyaluronate in the Treatment of Dry Eye Disease |
| QIN Genyan,JIANG Pengfei,PENG Jun,CHEN Lihao,LI Dongdong,LI Jie,PENG Qinghua |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Eye, Ear, Nose and Throat Diseases in Hunan Province, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To clinically evaluate pranoprofen combined with sodium hyaluronate and sodium hyaluronate alone for the treatment of dry eye disease. Methods A total of 180 patients with dry eye disease were randomly divided into an observation group and a control group. The observation group was treated with pranoprofen combined with sodium hyaluronate. The control group was treated with simple sodium hyaluronate. By comparing the changes of tear film rupture time, tear secretion test, corneal fluorescein staining score, and scores of dry eye disease symptoms before and after treatment in the 2 groups, the clinical efficacy of the 2 treatment methods were observed. Results The clinical effect rates of the 2 groups were 95.56% and 83.33%, respectively, and the observation group was better than the control group (P>0.05). In the comparison of the tear secretion test and tear film rupture time between the 2 groups at 2 and 4 weeks after treatment, the observation group was higher than the control group, and the difference was statistically significant (P<0.05); In the comparison of dry eye symptoms score and corneal fluorescein staining score at 2 and 4 weeks after treatment, the observation group was lower than the control group, and the difference was statistically significant (P<0.05). Conclusions For dry eye disease patients, from the analysis of clinical effective rate, scores of dry eye disease symptoms, tear secretion test, tear film rupture time and corneal fluorescein staining score, pranoprofen combined with sodium hyaluronate treatment program is better than the simple use of sodium hyaluronate, which is worthy of clinical promotion and application. |
| Key words: pranoprofen sodium hyaluronate dry eye disease tear film rupture time tear secretion test corneal fluorescein staining score scores of dry eye disease symptoms |
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