| 引用本文: |
刘永利,邵先舫,李前,敖雪,伍秋福,高大林.治伤巴布剂对急性软组织损伤患者血清TNF-α、IL-6水平的影响[J].湖南中医药大学学报,2020,40(3):377-380[点击复制] |
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| 治伤巴布剂对急性软组织损伤患者血清TNF-α、IL-6水平的影响 |
| 刘永利,邵先舫,李前,敖雪,伍秋福,高大林 |
| (湖南中医药大学, 湖南 长沙 410208;湖南中医药大学附属常德医院, 湖南 常德 415000;海口市人民医院重症医学科, 海南 海口 570208) |
| 摘要: |
| 目的 观察治伤巴布剂对急性软组织损伤（soft tissue injury，STI）患者体内血清肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）含量水平的影响，并初步探讨分析其活血化瘀、消肿止痛功效的作用机制。方法 选取湖南中医药大学附属常德医院骨伤科2018年6月至2019年6月住院的急性STI患者102例，按照随机、对照的原则分成观察组50例、对照组52例。对照组在入院第1 d开始予常规治疗，观察组在对照组基础上于第1 d开始加用治伤巴布剂外敷，1次/d，连续治疗14 d。分别在治疗前及治疗后7 d、14 d测定患者血清TNF-α、IL-6含量水平。结果 治疗前两组患者血清TNF-α、IL-6水平差异无统计学意义（P>0.05）；治疗后7 d、14 d，对比两组患者血清TNF-α、IL-6含量水平，差异有统计学意义（P<0.05）。结论 治伤巴布剂能改善急性STI患者血清TNF-α、IL-6含量水平。 |
| 关键词: 软组织损伤 治伤巴布剂 肿瘤坏死因子-α 白细胞介素-6 |
| DOI：10.3969/j.issn.1674-070X.2020.03.026 |
| 投稿时间：2019-08-09 |
| 基金项目:湖南省自然科学基金资助项目（2015JJ6087）；湖南中医药大学青年教师科研基金课题；湖南中医药大学研究生科研创新课题（2019CX16）；常德市科学技术局技术研究与开发资金项目（2012SK06，2017SK17）。 |
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| Effects of Curing-Injury Cataplasma on Serum TNF-α and IL-6 Levels in Patients with Acute Soft Tissue Injury |
| LIU Yongli,SHAO Xianfang,LI Qian,AO Xue,WU Qiufu,GAO Dalin |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Changde Hospital Affiliated to Hunan University of Chinese Medicine, Changde, Hunan 415000, China;Department of Intensive Care Unit, Haikou People's Hospital, Haikou, Hainan 570208, China) |
| Abstract: |
| Objective To observe the effects of curing-injury cataplasma on serum levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in patients with acute soft tissue injury (STI), and to initially study the mechanism of promoting blood circulation and removing blood stasis, reducing swelling and relieving pain. Methods A total of 102 patients with acute STI admitted to Changde Hospital Affiliated to Hunan University of Chinese Medicine from June 2018 to June 2019 were selected and divided into 50 patients in the observation group and 52 patients in the control group according to principle of randomization and control. After admission, the control group received conventional treatment. On the basis of the control group, curing-injury cataplasma was added to the observation group for external application, once a day and continuous treatment for 14 days. Serum TNF-α and IL-6 levels were detected before the treatment and the 7th and 14th day after treatment. Results Before the treatment, serum TNF-α and IL-6 levels in the two groups showed no statistically significant difference (P>0.05). On the 7th and 14th day after treatment, serum TNF-α and IL-6 levels in the two groups were decreased (P<0.05), and the observation group was lower than the control group (P<0.05). Conclusion The serum TNF-a and IL-6 levels in patients with acute STI can be improved by curing-injury cataplasma. |
| Key words: soft tissue injury curing-injury cataplasma tumor necrosis factor α interleukin-6 |
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