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曾志成,彭俊,姚小磊,彭清华.密蒙花颗粒离子导入对干眼患者泪液质量及基质金属蛋白酶-9表达的影响[J].湖南中医药大学学报,2020,40(3):364-368[点击复制] |
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| 密蒙花颗粒离子导入对干眼患者泪液质量及基质金属蛋白酶-9表达的影响 |
| 曾志成,彭俊,姚小磊,彭清华 |
| (湖南中医药大学, 湖南 长沙 410208;湖南中医药大学第一附属医院眼科, 湖南 长沙 410007) |
| 摘要: |
| 目的 观察中药密蒙花颗粒离子导入对干眼患者泪液质量及基质金属蛋白酶-9（matrix metrix metalloprotein，MMP-9）的影响及可能作用机制。方法 将70例（140眼）干眼患者随机分为治疗组（35例70眼）和对照组（35例70眼）。治疗组予以中药密蒙花颗粒离子导入和玻璃酸钠滴眼液点眼，对照组仅予以玻璃酸钠滴眼液点眼，共治疗4周。于治疗前及治疗2、4周后比较两组患者的干眼症状、基础泪液分泌（Schiemer-I）、泪膜破裂时间（break-up time，BUT）、角膜染色评分和泪液MMP-9表达情况，治疗4周后评价临床疗效。结果 治疗2、4周后，两组患者干眼症状评分、Schiemer-I、BUT、角膜染色评分和泪液MMP-9表达与本组治疗前比较均有改善（P<0.05或P<0.01），且不同时间点比较，治疗组均优于对照组（P<0.05或P<0.01）。治疗组总有效率为91.43%，对照组为80.00%，治疗组临床疗效优于对照组（P<0.05）。结论 中药密蒙花颗粒离子导入联合玻璃酸钠滴眼液点眼，可改善干眼患者干眼症状和泪液质量，降低泪液中MMP-9的表达，提高临床疗效，并且降低泪液中MMP-9的表达是其作用机制之一。 |
| 关键词: 干眼 密蒙花 泪液质量 基质金属蛋白酶-9 |
| DOI：10.3969/j.issn.1674-070X.2020.03.023 |
| 投稿时间：2019-08-11 |
| 基金项目:国家自然科学基金（30772824，81574031）；中医药防治五官科疾病湖南省重点实验室建设项目（2017TP1018）；中医药防治眼耳鼻咽喉疾病与视功能保护湖南省工程技术研究中心建设项目（2018TP2008）；中央财政支持地方高校建设项目（湘财教指〔2016〕75号）；国家中医药管理局中医眼科学重点学科建设项目（国中医药〔2009〕30号）；湖南省中医五官科学重点学科建设项目（湘财教指〔2015〕229号）；湖南中医药大学中医学国内一流建设学科（湘教通〔2018〕469号）；湖南中医药大学2019年“一方”研究生创新项目（研函〔2019〕8号）。 |
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| Effects of Flos Buddlejae Granules Iontophoresis on Tear Quality and Matrix Metalloprotein-9 Expression in Tears of Dry Eye Patients |
| ZENG Zhicheng,PENG Jun,YAO Xiaolei,PENG Qinghua |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Department of Ophthalmology, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To observe the effects of Flos Buddlejae Granules iontophoresis on tear quality and matrix metalloprotein-9 (MMP-9) expression in tears of dry eye patients. Methods A total of 70 cases (140 eyes) of dry eye patients were randomly divided into a treatment group (35 cases with 70 eyes) and a control group (35 cases with 70 eyes). The treatment group was given Chinese medicine Flos Buddlejae Granules iontophoresis and sodium hyaluronate eye drops, and the control group was only given sodium hyaluronate eye drops, for a total of 4 weeks' treatment. The dry eye symptoms, tear quality[foundation tear secretion (Schiemer-I), break-up time (BUT), the cornea dyeing scoring] and MMP-9 expression of the two groups were compared before treatment, 2 weeks, and 4 weeks after treatment. The clinical curative effect was evaluated after 4 weeks' treatment. Results After 2 and 4 weeks of treatment, the dry eye symptom score, Schiemer-I, BUT, corneal staining score and tear MMP-9 expression of the two groups were improved than before treatment (P<0.05 or P<0.01), and at different time points, the treatment group was better than he control group (P<0.05 or P<0.01). The total effective rate of the treatment group was 91.43%, and the control group was 80.00%. The clinical efficacy of the treatment group was better than the control group (P<0.05). Conclusion The combination of Flos Buddlejae Granules iontophoresis and sodium hyaluronate eye drops can improve dry eye symptoms and tear quality in dry eye patients, reduce the expression of MMP-9 in tears, improve clinical efficacy, and reducing the expression of MMP-9 in tears is one of its mechanisms. |
| Key words: dry eyes Flos Buddlejae tear quality matrix metalloprotein-9 |
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