| 引用本文: |
龚彩弟,陈虹彤,熊冲,胡军福,张威英,钟建.益气养阴法加西医常规治疗IgA肾病的系统评价[J].湖南中医药大学学报,2019,39(12):1476-1482[点击复制] |
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| 益气养阴法加西医常规治疗IgA肾病的系统评价 |
| 龚彩弟,陈虹彤,熊冲,胡军福,张威英,钟建 |
| (广西中医药大学研究生院, 广西 南宁 530001;广西中医药大学第一附属医院, 广西 南宁 530023) |
| 摘要: |
| 目的 系统评价中医益气养阴法治疗IgA肾病的有效性。方法 计算机检索中国知网数据库、万方数据库、维普全文数据库、中国生物医学文献数据、PubMed、EMbase等数据库建库至2019年9月20日所纳入的关于益气养阴法治疗IgA肾病的随机对照研究，并且按照纳入和排除标准进行数据提取，再根据Cochrane手册提供的质量标准评价所纳入的研究的方法学质量，采用RevMan 5.3软件进行Meta分析。结果 最终纳入15个随机对照试验，共1 032例患者，Meta分析结果显示：与对照组相比，中医益气养阴法在降低IgA肾病患者的24 h尿蛋白定量、尿红细胞数和血清肌酐，提高临床有效率等方面优于单纯西医治疗。结论 中医益气养阴法治疗IgA肾病与单纯西医治疗相比具有一定优势，但是由于所纳入研究样本量较小且方法学质量较低，以上结论仍需大样本、多中心、高质量的随机双盲对照试验加以证实。 |
| 关键词: IgA肾病 益气养阴法 Meta分析 随机对照试验 |
| DOI：10.3969/j.issn.1674-070X.2019.12.013 |
| 投稿时间：2019-08-06 |
| 基金项目:国家自然科学基金项目（81760807，81360536）。 |
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| Treatment of IgA Nephropathy byBenefiting Qi and Nourishing Yin Method and Western Medicine Conventional Treatment: A Systematic Review |
| GONG Caidi,CHEN Hongtong,XIONG Chong,HU Junfu,ZHANG Weiying,ZHONG Jian |
| (Graduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi 530001, China;The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi 530023, China) |
| Abstract: |
| Objective To assess the efficacy of benefiting Qi and nourishing Yin method for the treatment of IgA nephropathy. Methods We searched the databases of CNKI, WanFang Data, VIP, CBMdisc, PubMed, EMbase and other databases for the treatment of IgA nephropathy by benefiting Qi and nourishing Yin method for randomized controlled trials. The search period was from the date of establishment to September 20, 2019. According to inclusion and exclusion criteria, the data was extracted. According to Cochrane handbook, the methodological quality of the included studies was evaluated. RevMan 5.3 software was used for meta-analysis. Results Finally, 15 randomized controlled trials (RCTs) were included, with a total of 1032 patients, Meta-analysis results showed that compared with the control group, the treatment of IgA nephropathy by benefiting Qi and nourishing Yin method in reduction of IgA nephropathy patients 24 hours urine protein, urine red blood cell count, serum creatinine and improving clinical efficiency was better than pure western medicine treatment. Conclusion The treatment of IgA nephropathy by benefiting Qi and nourishing Yin method has certain advantages compared with western medicine treatment, but as a result of the included studies with smaller sample size and low methodological quality, the above conclusion still needs large sample, multicenter, high quality randomized double-blind controlled trials to confirm. |
| Key words: IgA nephropathy benefiting Qi and nourishing Yin method Meta-analysis randomized controlled trial |
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