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梁谋,杨柳,刘杨,简维雄,吴彬才,黄赛男,梁恩军.刘新祥教授治疗水肿病的用药组方规律分析[J].湖南中医药大学学报,2019,39(11):1362-1367[点击复制] |
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| 刘新祥教授治疗水肿病的用药组方规律分析 |
| 梁谋,杨柳,刘杨,简维雄,吴彬才,黄赛男,梁恩军 |
| (广州中医药大学顺德医院肾内科, 广东 佛山 528333;长沙民政职业技术学院, 湖南 长沙 410007;湖南中医药大学第二附属医院, 湖南 长沙 410005;湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 目的 基于数据挖掘技术应用中医传承辅助系统软件分析刘新祥主任医师治疗水肿病的用药及组方规律。方法 收集整理刘新祥教授2013年1月-2018年12月治疗的120例水肿病人首次处方用药情况，基于数据挖掘技术运用“中医传承辅助平台（V2.5）”的关联规则、改进互信息法、复杂系统熵聚类等无监督数据方法挖掘刘新祥教授治疗水肿病用药组方规律。结果 对符合要求的120例水肿病患者首次处方进行分析，得出相关用药情况及药物间的关系。刘新祥教授治疗水肿病最常用的药物分别是：黄芪、甘草、山药、芡实、当归、丹参、党参、土茯苓、益母草、怀牛膝等；通过规则分析可知其用药时党参一般均与黄芪、甘草、山药、当归、丹参、芡实连用；并得到治疗水肿病新方：肉苁蓉、山茱萸、瓜蒌子、怀牛膝，芡实、白芍、山药、茯苓，地榆炭、阿胶、侧柏炭、蒲黄炭，丹参、生姜皮、冬瓜皮、益母草等11首。结论 刘新祥教授善于从脾肾双补角度用药，尤擅于健运脾土以治疗水肿病。 |
| 关键词: 水肿病 肾系病症 刘新祥 慢性肾小球肾炎 数据挖掘技术 |
| DOI：10.3969/j.issn.1674-070X.2019.11.016 |
| 投稿时间：2019-03-03 |
| 基金项目:广东省中医药局2015年建设中医药强省科研课题（20152106）。 |
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| Analysis on Professor LIU Xinxiang's Medication Rules in the Treatment of Patients with Edema |
| LIANG Mou,YANG Liu,LIU Yang,JIAN Weixiong,WU Bincai,HUANG Sainan,LIANG Enjun |
| (Department of Nephrology, Shunde Hospital of Guangzhou University of Chinese Medicine, Foshan, Guangdong 528333, China;Changsha Social Work College, Changsha, Hunan 410007, China;The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410005, China) |
| Abstract: |
| Objective To analyze the medication rules of chief physician LIU Xinxiang's treatment of edema disease by applying the traditional Chinese medicine inheritance support system based on data mining technology. Methods The first-time prescriptions of 120 patients with edema who received the treatment by Professor LIU from January 2013 to December 2018 were collected. Based on data mining technology, unsupervised data mining methods from the traditional Chinese medicine inheritance support system (V2.5) such as the association rules, improved mutual information method and complex system entropy clustering were used to explore the medication rules of LIU Xinxiang's treatment of edema. Results The first-time prescriptions for 120 qualified cases with edema were analyzed. Through analyzing, information about drug usage and relationship between different drugs were obtained. Professor LIU's most commonly used drugs for treating edema were:Radix Astragali seu Hedysari, Radix Glycyrrhizae, Rhizoma Dioscoreae, Semen Euryales, Radix Angelicae Sinensis, Radix Salviae miltiorrhizae, Radix Codonopsis, Rhizoma Smilacis Glabrae, Herba Leonuri, Radix Achyranthis Bidentatae, etc. According to the association rules, Radix Codonopsis was generally used combining with Radix Astragali seu Hedysari, Radix Glycyrrhizae, Rhizoma Dioscoreae, Radix Angelicae Sinensis, Radix Salviae miltiorrhizae and Semen Euryales. In addition, 11 new prescriptions for treating edema were obtained. To name some of them:Herba Cistanches, Fructus Corni, Semen Trichosanthis, Radix Achyranthis Bidentatae; Semen Euryales, Radix Paeoniae Alba, Rhizoma Dioscoreae, Poria; Radix Sanguisorbae, Colla Corii Asini, Platycladus Orientalis, Pollen Typhae; Radix Salviae Miltiorrhizae, Rhizoma Zingiberis Recens, Exocarpium Benincasae, Herba Leonuri. Conclusion Professor LIU Xinxiang is good at invigorating spleen and kidney, especially at invigorating spleen earth to treat edema. |
| Key words: edema nephropathy LIU Xinxiang chronic glomerulonephritis data mining |
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