| 引用本文: |
陈玲,唐雷,徐派的,许珍珍.木香顺气散联合恒温雷火灸对萎缩性胃炎血清胃泌素-17及胃蛋白酶原的影响[J].湖南中医药大学学报,2019,39(9):1133-1137[点击复制] |
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| 木香顺气散联合恒温雷火灸对萎缩性胃炎血清胃泌素-17及胃蛋白酶原的影响 |
| 陈玲,唐雷,徐派的,许珍珍 |
| (湖北省荆州市中医医院, 湖北 荆州 434000;华中科技大学同济医学院附属武汉市中心医院 湖北 武汉 430014;湖北中医药大学针灸骨伤学院, 湖北 武汉 430065) |
| 摘要: |
| 目的 探讨木香顺气散联合恒温雷火灸治疗萎缩性胃炎的临床疗效及对患者血清胃泌素-17（gastrin-17，G-17）、胃蛋白酶原（Pepsinogen，PG）的影响。方法 将萎缩性胃炎患者90例随机分为对照组和观察组，各45例。对照组口服雷贝拉唑，20 mg/次，早7点与晚9点服用；阿莫西林：1 g/次；克拉霉：0.5 g/次，均早餐与晚餐1 h后服用。观察组在对照组基础上采取木香顺气散与恒温雷火灸治疗，木香顺气散：8 g/次，三餐前开水冲服；恒温雷火灸：取双侧足三里、神阙、中脘四穴，1次/d，10~20 min/次。两组患者均连续治疗2周，比较两组患者治疗后中医症状积分、临床疗效及幽门螺杆菌（Helicobactor pylori，Hp）转阴率，检测两组患者治疗前后的G-17及PGI、PGⅡ、PGⅠ/PGⅡ比值水平。结果 观察组总有效率为95.56%，明显高于对照组的77.78%（P<0.05）。治疗后，两组患者中医症状积分均较治疗前下降，且观察组症状积分显著低于对照组（P<0.01）；两组患者G-17、PGⅠ、PGⅠ/PGⅡ比值水平均较治疗前升高，观察组PGⅡ较治疗前升高（P<0.01），且观察组G-17、PGI、PGⅡ、PGⅠ/PGⅡ比值水平均高于对照组（P<0.01）；观察组Hp根除率高于对照组（P<0.01）。结论 木香顺气散联合恒温雷火灸治疗萎缩性胃炎，可促进患者血清G-17及PG水平的提高，避免胃黏膜进一步萎缩，提高了综合疗效。 |
| 关键词: 萎缩性胃炎 木香顺气散 恒温雷火灸 血清胃泌素-17 胃蛋白酶原 |
| DOI：10.3969/j.issn.1674-070X.2019.09.018 |
| 投稿时间：2019-01-04 |
| 基金项目:国家自然科学基金资助项目（81704178）。 |
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| Effects of Muxiang Shunqi Powder Combined with Constant Temperature Thunder-fire Moxibustion on Serum Gastrin-17 and Pepsinogen in Patients with Atrophic Gastritis |
| CHEN Ling,TANG Lei,XU Paidi,XU Zhenzhen |
| (Jingzhou Hospital of Traditional Chinese Medicine, Jingzhou, Hubei 434000, China;The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China;College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei 430065, China) |
| Abstract: |
| Objective To investigate the clinical efficacy of Muxiang Shunqi Powder combined with constant temperature thunder-fire moxibustion in atrophic gastritis and its effects on serum gastrin-17 (G-17) and pepsinogen (PG). Methods A total of 90 patients with atrophic gastritis were randomly divided into control group (45 cases) and observation group (45 cases). The control group was orally given rabeprazole 20 mg/time at 7 a.m. and 9 p.m., and amoxicillin 1 g/time and clarithromycin 0.5 g/time at 1 h after breakfast and dinner. The observation group was treated with Muxiang Shunqi Powder and constant temperature thunder-fire moxibustion on the treatment basis of the control group. Muxiang Shunqi Powder:8 g/time, taking after mixing it with boiling water before 3 meals. Constant temperature thunder-fire moxibustion:Zusanli (ST 36), Shenque (CV 8) and Zhongwan (CV 12) on both sides were selected 1 time/d, 10-20 min/time. Both groups were treated for 2 weeks. Scores of traditional Chinese medicine (TCM) symptom, clinical efficacy and negative conversion rates of Helicobactor pylori (Hp) were compared between the 2 groups. Levels of G-17, PGI, PGⅡ and PGI/PGⅡ in the 2 groups were detected before and after the treatment. Results The total effective rate in the observation group was 95.56%, which was significantly higher than 77.78% in the control group (P<0.05). After the treatment, the scores of TCM symptom in the 2 groups were decreased compared to those before the treatment, and the score in the observation group was significantly lower than that in the control group (P<0.01); the levels of G-17, PGI and PGI/PGⅡ were increased compared to those before the treatment, and the PGⅡ in the observation group was higher than that before the treatment (P<0.01); the levels of G-17, PGI, PGⅡ and PGI/PGⅡ in the observation group were higher than those in the control group (P<0.01); the eradication rate of Hp in the observation group was higher than that in the control group (P <0.01). Conclusion Muxiang Shunqi Powder combined with constant temperature thunder-fire moxibustion can improve the level of serum gastrin-17 and pepsinogen in patients with atrophic gastritis, avoid further atrophy of gastric mucosa and improve the comprehensive efficacy. |
| Key words: atrophic gastritis Muxiang Shunqi Powder constant temperature thunder-fire moxibustion serum gastrin-17 pepsinogen |
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