| 引用本文: |
杨逸璇,朱明芳,王峰,朱亚梦,黄晓婵,杨婉婷.石榴皮多酚软膏通过介导TGF-β/Smad信号通路以抗痤疮瘢痕形成的机制研究[J].湖南中医药大学学报,2019,39(5):596-599[点击复制] |
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| 石榴皮多酚软膏通过介导TGF-β/Smad信号通路以抗痤疮瘢痕形成的机制研究 |
| 杨逸璇,朱明芳,王峰,朱亚梦,黄晓婵,杨婉婷 |
| (湖南中医药大学, 湖南 长沙 410208;湖南中医药大学第二附属医院, 湖南 长沙 410005) |
| 摘要: |
| 目的 探讨不同浓度的石榴皮多酚软膏抗增生性痤疮瘢痕形成的机制。方法 SD大鼠36只，于烫伤造模成功后，随机分为模型组，阴性对照组及石榴皮软膏低剂量组、中剂量组、高剂量组、超高剂量组6组，每组6只。模型组给予生理盐水湿敷，阴性对照组涂1 mL基质，石榴皮软膏组按低、中、高、超高剂量组每日分别给予1 mL的相应浓度的石榴皮多酚软膏1次。自造模日起观察创面情况，并于造模后第7、14、21天分别取各组大鼠创面皮肤进行病理组织学检测及免疫组化检测TGF-β1、Smad4水平。结果 石榴皮多酚软膏中剂量组能降低TGF-β1、Smad4表达（P<0.05），抑制瘢痕形成。结论 石榴皮多酚软膏可以通过调控TGF-β/Smad信号通路抗增生性痤疮瘢痕的形成。 |
| 关键词: 痤疮瘢痕 增生性瘢痕 TGF-β/Smad信号通路 石榴皮多酚 |
| DOI：10.3969/j.issn.1674-070X.2019.05.007 |
| 投稿时间：2018-11-11 |
| 基金项目:湖南省中医药管理局科研项目计划（201705）；湖南省教育厅科学研究项目（18A212） |
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| Mechanisms of Pomegranate Peel Polyphenol Ointment in Preventing Acne Scar Formation by Mediating TGF-β/Smad Signaling Pathway |
| YANG Yixuan,ZHU Mingfang,WANG Feng,ZHU Yameng,HUANG Xiaochan,YANG Wanting |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410005, China) |
| Abstract: |
| Objective To investigate the mechanism of different concentrations of pomegranate peel polyphenol ointment in preventing hypertrophic acne scar formation. Methods After successful scald molding, 36 SD rats were randomly divided into a model group, a negative control group, a low dose, a medium dose, a high dose of pomegranate peel ointment group, with 6 rats in each group. The model group was given normal saline wet compress, and the negative control group was coated with 1 mL matrix, and the pomegranate peel ointment group was given 1 mL pomegranate peel polyphenol ointment of the corresponding concentration in the low, medium, high and ultra-high dose groups respectively. The wound condition was observed from the day of model establishment, and the wound skin of rats in each group was taken on the 7th, 14th and 21st day after model establishment for histopathological examination and immunohistochemical detection of transforming growth factor-β1 (TGF-β1) and Smad4 levels. Results The middle dose group of pomegranate peel polyphenol ointment could decrease the expression of TGF-β1 and Smad4 (P<0.05), and inhibit the formation of scar. Conclusion Pomegranate peel polyphenol ointment may inhibit the formation of acne scars by regulating TGF-β/Smad signaling pathway. |
| Key words: acne scar hypertrophic scar TGF-β/Smad signaling pathway pomegranate peel polyphenol |
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