| 引用本文: |
杨硕.细胞自噬与多囊卵巢综合征研究进展[J].湖南中医药大学学报,2019,39(3):425-428[点击复制] |
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| 细胞自噬与多囊卵巢综合征研究进展 |
| 杨硕 |
| (湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 多囊卵巢综合征（Polycystic ovary syndrome，PCOS）是导致女性月经不调、排卵障碍性不孕的主要原因，确切发病机制尚未阐明。自噬可以发生在卵泡发育的各个阶段，卵泡颗粒细胞自噬相对活跃，具有促性腺激素依赖性和细胞特异性。卵泡颗粒细胞自噬稳态平衡以维持卵巢功能，调控卵泡发育，影响胚胎质量和妊娠结局。PCOS卵泡颗粒细胞自噬活性过高，自噬相关基因表达过强，与PCOS卵泡发育异常、内分泌代谢紊乱、临床自然流产率高和辅助生殖中发生卵巢过度刺激综合征风险增高密切相关，可能是PCOS发病的重要机制。补肾中药通过下调PCOS卵泡颗粒细胞过度自噬，改善卵巢功能，维持机体阴阳平衡，但具体作用机制亟待进一步阐明，为PCOS、不孕症等妇科疑难病症临床诊疗提供新思路。 |
| 关键词: 多囊卵巢综合征 卵泡颗粒细胞自噬 卵泡发育 补肾中药 |
| DOI：10.3969/j.issn.1674-070X.2019.03.031 |
| 投稿时间：2018-08-28 |
| 基金项目:国家自然科学基金资助项目（81503611）；湖南省自然科学基金资助项目（2015JJ6078）；湖南省教育厅科学研究基金资助项目（15B180） |
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| Research Advances in Cell Autophagy and Polycystic Ovary Syndrome |
| YANG Shuo |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Polycystic ovary syndrome (PCOS) is the main cause of irregular menstruation and ovulatory dysfunctional infertility in women, and its pathogenesis remains unclear. Autophagy can occur at all stages of follicular development, and autophagy of follicular granulosa cells is relatively active, which has gonadotropin dependence and cell specificity. Homeostasis of follicular granulosa cell autophagy plays an important role in maintaining ovarian function and regulating follicular development and can affect embryo quality and pregnancy outcome. High activity of follicular granulosa cells and high expression of autophagy-related genes are observed in patients with PCOS and are closely associated with follicular dysplasia, endocrine and metabolic disorders, a high rate of spontaneous abortion in clinical practice, and an increased risk of ovarian hyperstimulation syndrome during assisted reproduction, which may be an important pathogenesis of PCOS. Kidney-tonifying traditional Chinese herbs can improve ovarian function and maintain Yin-Yang balance by downregulating excessive autophagy of follicular granulosa cells, but the specific mechanism needs to be further clarified, in order to provide new ideas for clinical diagnosis and treatment of difficult gynecological diseases such as PCOS and infertility. |
| Key words: polycystic ovary syndrome follicular granulosa cell autophagy follicular development kidney-tonifying traditional Chinese medicine |
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