| 引用本文: |
余建萍,张黎黎,何仲春,刘磊.开窍醒神汤联合丁苯酞注射液治疗脑梗死急性期的临床疗效及其对NSE、炎性因子表达的影响[J].湖南中医药大学学报,2018,38(12):1448-1452[点击复制] |
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| 开窍醒神汤联合丁苯酞注射液治疗脑梗死急性期的临床疗效及其对NSE、炎性因子表达的影响 |
| 余建萍,张黎黎,何仲春,刘磊 |
| (成都医学院第一附属医院, 四川 成都 610500) |
| 摘要: |
| 目的 探讨开窍醒神汤联合丁苯酞治疗脑梗死急性期的临床疗效及其对神经元特异性醇化酶（NSE）、炎性因子表达的影响。方法 选择2016年1月至2016年12月我院接诊的94例脑梗死急性期患者作为研究对象，将其随机分为观察组和对照组，每组47例。在常规治疗的基础上，对照组单纯加用丁苯酞注射液，观察组在对照组基础上加用开窍醒神汤。治疗后，比较两组临床疗效、血液流变学指标、NIHSS评分、NSE、肿瘤坏死因子（TNF-α）、超敏C反应蛋白（hs-CRP）、白介素-6（IL-6）水平及安全性发生情况。结果 治疗后，观察组总有效率高于对照组，差异有统计学意义（P<0.05）；观察组血浆黏度、全血高切黏度、全血低切黏度、红细胞压积水平均低于对照组，差异有统计学意义（P<0.05）；观察组NIHSS评分、NSE水平、TNF-α、hs-CRP、IL-6均低于对照组，差异有统计学意义（P<0.05）；两组患者治疗过程中均未出现脑出血等不良事件。结论 开窍醒神汤联合丁苯酞注射液可有效改善脑梗死急性期患者血液流变学指标，降低炎性因子表达，从而减轻由炎症介质引起的脑损伤，促进神经功能的恢复，值得临床推广。 |
| 关键词: 脑梗死 开窍醒神汤 丁苯酞 急性期 血液流变学 炎性因子 |
| DOI：10.3969/j.issn.1674-070X.2018.12.022 |
| 投稿时间：2018-03-27 |
| 基金项目: |
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| Clinical efficacy of Kaiqiao Xingshen Decoction Combined with Butylphthalide Injection in Treatment of Acute Cerebral Infarction and Its Effects on the Expression of NSE and Inflammatory Factors |
| YU Jianping,ZHANG Lili,HE Zhongchun,LIU Lei |
| (The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, China) |
| Abstract: |
| Objective To investigate the clinical efficacy of Kaiqiao Xingshen Decoction combined with butyphthalide injection in the treatment of acute cerebral infarction and its effects on the expression of neuron-specific enolase (NSE) and inflammatory factors.Methods A total of 94 patients with acute cerebral infarction who were admitted to our hospital from January to December, 2016 were equally and randomly divided into observation group and control group. On the basis of conventional treatment, the control group was administered butylphthalide injection alone, while the observation group was administered butylphthalide injection combined with Kaiqiao Xingshen Decoction. After treatment, the clinical outcome, hemorheological indices, National Institutes of Health Stroke Scale (NIHSS) score, the levels of NSE, tumor necrosis factor-alpha (TNF-α), high-sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6), and adverse events were compared between the two groups.Results After treatment, compared with the control group, the observation group had a significantly higher overall response rate (P<0.05); the observation group had significantly lower plasma viscosity, whole blood high-shear viscosity, whole blood low-shear viscosity, hematocrit, NIHSS score, and levels of NSE, TNF-α, hs-CRP, and IL-6 (P<0.05). No adverse events such as cerebral hemorrhage were observed in either group during treatment.Conclusion For patients with acute cerebral infarction, Kaiqiao Xingshen Decoction combined with butylphthalide injection can effectively improve hemorheological indices and reduce the expression of inflammatory factors, thereby alleviating the brain injury caused by inflammatory mediators and promoting the recovery of neurological function. It has good efficacy, and thus holds promise for clinical application. |
| Key words: cerebral infarction Kaiqiao Xingshen Decoction butylphthalide acute stage hemorheology inflammatory factor |
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