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李金贵,万华,吴克.复方金钱草颗粒联合枸橼酸氢钾钠颗粒对上尿路结石患者ESWL术后残留结石排出及复发的影响[J].湖南中医药大学学报,2018,38(9):1062-1065[点击复制] |
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| 复方金钱草颗粒联合枸橼酸氢钾钠颗粒对上尿路结石患者ESWL术后残留结石排出及复发的影响 |
| 李金贵,万华,吴克 |
| (成都市天府新区人民医院, 四川 成都 610213) |
| 摘要: |
| 目的 探讨复方金钱草颗粒联合枸橼酸氢钾钠颗粒对上尿路结石患者体外冲击波碎石（ESWL）术后残留结石排出及复发的影响。方法 选取2012年1月至2016年1月本院收治行ESWL术的上尿路结石患者120例，按照随机数字表法分为观察组和对照组各60例。对照组患者服用复方金钱草颗粒治疗，观察组患者在对照组基础上联合服用枸橼酸氢钾钠颗粒治疗。两组均连续治疗14 d。比较两组治疗临床疗效、结石首次排出时间、结石排净时间、肾绞痛发生率、VAS评分以及治疗后第3个月、6个月、12个月结石复发率。结果 观察组治疗总有效率为86.7%，对照组为71.7%，差异有统计学意义（P<0.05）；观察组结石首次排出时间和结石排净时间均显著短于对照组（P<0.05）；观察组肾绞痛发生率及VAS评分均显著低于对照组（P<0.05）；观察组治疗后1年内结石复发率为3.33%，显著低于对照组的13.33%（P<0.05）。结论 上尿路结石患者ESWL术后采用复方金钱草颗粒联合枸橼酸氢钾钠颗粒治疗，疗效显著，可促进结石排出，缩短结石排净时间，减少疼痛发生，减轻疼痛程度，且有效降低术后1年内结石复发率。 |
| 关键词: 上尿路结石 体外冲击波碎石术 复方金钱草颗粒 枸橼酸氢钾钠颗粒 复发率 |
| DOI：10.3969/j.issn.1674-070X.2018.09.021 |
| 投稿时间：2018-04-09 |
| 基金项目:四川省医学科研课题（S16017）。 |
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| Effect of Compound Lysimachia christinae Granule Combined with Potassium Sodium Hydrogen Citrate Granule on Excretion and Recurrence of Residual Stones After Extracorporeal Shock Wave Lithotripsy in Patients with Upper Urinary Tract Calculi |
| LI Jingui,WAN Hua,WU Ke |
| (Chengdu Tianfu New District People's Hospital, Chengdu, Sichuan 610213, China) |
| Abstract: |
| Objective To investigate the effect of compound Lysimachia christinae Granule combined with potassium sodium hydrogen citrate granule on excretion and recurrence of residual stones after extracorporeal shock wave lithotripsy (ESWL) in patients with upper urinary tract calculi. Methods From January 2012 to January 2016, 120 patients with upper urinary tract calculi admitted to our hospital for ESWL were enrolled and equally divided into observation group and control group using a random number table. Both groups were treated with compound Lysimachia christinae Granule for 14 continuous days, while the observation group was additionally treated with potassium sodium hydrogen citrate granule. The clinical outcomes, time to the first stone discharge, time to stone clearance, incidence of renal colic, Visual Analogue Scale (VAS) score, and recurrence rates of stones at 3, 6, and 12 months after treatment were compared between the two groups. Results The observation group had a significantly higher overall response rate than the control group (86.7% vs 71.7%, P<0.05). The observation group had significantly shorter time to the first stone discharge and stone clearance than the control group (P<0.05). The incidence of renal colic and the VAS score were significantly lower in the observation group than in the control group (P<0.05). Within one year after treatment, the observation group had a significantly lower recurrence rate than the control group (3.33% vs 13.33%, P<0.05). Conclusion Compound Lysimachia christinae Granule combined with potassium sodium hydrogen citrate granule achieves satisfactory treatment outcomes in patients with upper urinary tract calculi undergoing ESWL. The combination therapy can promote stone discharge, shorten the time to stone clearance, reduce the incidence and severity of pain, and effectively reduce the recurrence rate of stones within one year after surgery. |
| Key words: upper urinary tract calculi extracorporeal shock wave lithotripsy compound Lysimachia christinae Granule potassium sodium hydrogen citrate granule recurrence rate |
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