| 引用本文: |
李小东,苏新平,谭旭仪,罗海伟.止痛健骨方治疗痰瘀互结型膝关节滑膜炎临床观察[J].湖南中医药大学学报,2018,38(8):908-912[点击复制] |
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| 止痛健骨方治疗痰瘀互结型膝关节滑膜炎临床观察 |
| 李小东,苏新平,谭旭仪,罗海恩,何灿宇,黄刚,张道伟 |
| (湖南中医药大学, 湖南 长沙 410208;湖南省中医药研究院附属医院, 湖南 长沙 410006) |
| 摘要: |
| 目的 观察止痛健骨方治疗膝关节滑膜炎（痰瘀互结型）的临床疗效。方法 膝关节滑膜炎（痰瘀互结型）患者共64例，将其随机分为治疗组和对照组，每组32例。对照组治以膝关节穿刺术并联合塞来昔布胶囊口服，治疗组在对照组的基础上配合止痛健骨方口服，两组疗程均为28 d。对两组治疗结束后的疗效及治疗14 d、28 d的观察指标进行统计分析。结果 两组总有效率差异无统计学意义（P>0.05）；治疗组的临床治愈率明显高于对照组（P<0.05）。治疗后14 d、28 d，两组膝关节周径、VAS评分、WOMAC评分、关节液中IL-1及TNF-α的含量均较治疗前下降（P<0.05）；两组治疗后14 d、28 d，关节VAS疼痛评分、WOMAC评分、关节液中IL-1与TNF-α的含量比较，治疗组下降程度均大于对照组（P<0.05）。治疗后14 d两组间关节周径对比差异无统计学意义（P>0.05）；治疗后28 d，治疗组平均膝关节周径短于对照组（P<0.05）。结论 止痛健骨方配合塞来昔布胶囊联合膝关节穿刺术治疗痰瘀互结型膝关节滑膜炎，疗效优于塞来昔布胶囊联合膝关节穿刺术；止痛健骨方治疗痰瘀互结型膝关节滑膜炎具有良好的效果及安全性。 |
| 关键词: 膝关节滑膜炎 止痛健骨方 关节穿刺术 痰瘀互结 临床观察 |
| DOI：10.3969/j.issn.1674-070X.2018.08.016 |
| 投稿时间：2018-02-01 |
| 基金项目:国家自然科学基金项目（81603482）；湖南省自然科学基金项目（2016JJ6115，2015JJ6057）。 |
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| Clinical Effect of Zhitong Jiangu Decoction in Treatment of Knee Synovitis with the Syndrome of Intermingled Phlegm and Blood Stasis |
| LI Xiaodong,SU Xinping,TAN Xuyi,LUO Haien,HE Canyu,HUANG Gang,ZHANG Daowei |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The Affiliated Hospital of Hunan Academy of Chinese Medicine, Changsha, Hunan 410006, China) |
| Abstract: |
| Objective To investigate the clinical effect of Zhitong Jiangu Decoction in the treatment of knee synovitis with the syndrome of intermingled phlegm and blood stasis. Methods A total of 64 patients with knee synovitis with the syndrome of intermingled phlegm and blood stasis were enrolled and randomly divided into treatment group and control group, with 32 patients in each group. The patients in the control group were given knee joint cavity paracentesis combined with celecoxib capsules, and those in the treatment group were given Zhitong Jiangu Decoction in addition to the treatment in the control group. The course of treatment was 28 days for both groups. A statistical analysis was performed for clinical outcome after treatment and observation indices on days 14 and 28 of treatment. Results There was no significant difference in overall response rate between the two groups (P>0.05), and the treatment group had a significantly higher clinical cure rate than the control group (P<0.05). On days 14 and 28 of treatment, both groups had significant reductions in the circumference of the knee, Visual Analogue Scale (VAS) score, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and levels of interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) in the synovial fluid (P<0.05), and the treatment group had significantly greater reductions in VAS score, WOMAC, and levels of IL-1 and TNF-α in the synovial fluid than the control group (P<0.05). On day 14 of treatment, there was no significant difference in the circumference of the knee between the two groups (P>0.05), and on day 28 of treatment, the treatment group had a significantly shorter mean circumference of the knee than the control group (P<0.05). Conclusion Zhitong Jiangu Decoction combined with celecoxib capsules and knee joint cavity paracentesis has a better clinical effect than celecoxib capsules combined with knee joint cavity paracentesis in the treatment of knee synovitis with the syndrome of intermingled phlegm and blood stasis. Zhitong Jiangu Decoction has good efficacy and safety in the treatment of knee synovitis with the syndrome of intermingled phlegm and blood stasis. |
| Key words: knee joint synovitis Zhitong Jiangu Decoction knee joint cavity paracentesis syndrome of intermingled phlegm and blood stasis clinical observation |
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