| 引用本文: |
张可人,张依人,彭买姣,陈叶童,毛文点,钟源,阳佑华,邹龙.陶瓷膜分离技术精制古汉养生精提取液的工艺研究[J].湖南中医药大学学报,2018,38(8):875-878[点击复制] |
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| 陶瓷膜分离技术精制古汉养生精提取液的工艺研究 |
| 张可人,张依人,彭买姣,陈叶童,毛文点,钟源,阳佑华,邹龙 |
| (湖南中医药大学, 湖南 长沙 410208;启迪古汉集团衡阳中药有限公司, 湖南 衡阳 421003;湖南省中药液体制剂工程技术研究中心, 湖南 衡阳 421003) |
| 摘要: |
| 目的 采用陶瓷膜分离技术优化古汉养生精提取液的分离精制工艺，降低生产成本，提高提取液的澄清度。方法 对陶瓷膜孔径、药液浓度、温度进行考察，以淫羊藿苷转移率、多糖及蛋白质去除率、浸膏得率为评价指标，通过正交实验优化古汉养生精提取液的纯化工艺。结果 古汉养生精提取液陶瓷膜分离的最佳工艺参数为膜孔径500 nm、料液比1∶15、温度25℃。在此优化条件下古汉养生精的淫羊藿苷平均转移率为（92.4±0.6）%，RSD 1.15%；多糖平均去除率（70.4±0.7）%，RSD 1.26%；蛋白平均去除率（23.5±0.2）%，RSD 1.30%；浸膏平均得率（17.6±0.2）%，RSD 1.50%；综合评分0.1837。结论 采用陶瓷膜技术精制古汉养生精提取液工艺稳定可行，可为古汉养生生精工业化生产技术优化提供科学依据。 |
| 关键词: 古汉养生精口服液 陶瓷膜 淫羊藿苷 |
| DOI：10.3969/j.issn.1674-070X.2018.08.008 |
| 投稿时间：2018-06-25 |
| 基金项目:湖南省科技厅县域经济发展技术创新引导专项项目（2015SK2094）。 |
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| Process Parameters of Ceramic Membrane Separation Technique for Purification of Ancient Han Health-keeping Extract |
| ZHANG Keren,ZHANG Yiren,PENG Maijiao,CHEN Yetong,MAO Wendian,ZHONG Yuan,YANG Youhua,ZOU Long |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hengyang Traditional Chinese Medicine Co., Ltd., Tus-Guhan Group Corporation, Hengyang, Hunan 421003, China;Hunan Engineering & Technology Research Center for Traditional Chinese Medicine Liquid Preparation, Hengyang, Hunan 421003, China) |
| Abstract: |
| Objective To investigatethe separation and purification processof ancient Han health-keeping extract by ceramic membrane separation technique, in order to reduce production costs and improve the clarity of this extract. Methods The pore size of ceramic membrane, solid-liquid ratio, and temperature were analyzed, and with the transferring rate of icariin, removal efficiency of polysaccharides and protein, and extract yield as assessment indices, an orthogonal experiment was performed to optimize the purification process for ancient Han health-keeping extract. Results The optimal process parameters for ceramic membrane separation for ancient Han health-keeping extractwere a membrane pore size of 500 nm, a solid-liquid ratio of 1:15, and a temperature of 25℃. Under these optimized conditions, the mean transferring rate of icariin was (92.4±0.6)% (RSD=1.15%), the mean removal efficiencies of polysaccharides and protein were (70.4±0.7)% (RSD=1.26%) and (23.5±0.2)% (RSD=1.30%), respectively, and the mean extract yield was (17.6±0.2)% (RSD=1.50%); the comprehensive score was 0.1837. Conclusion Ceramic membrane separation technique is stable and feasible in the preparation of ancient Han health-keeping extract and provides a scientific basis for the optimization of industrial production technique for ancient Han health-keeping extract. |
| Key words: ancient Han health-keeping extract oral liquid ceramic membrane icariin |
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