| 引用本文: |
黄晋琰,林夏静,徐珉.仙子益真胶囊对卵巢早衰小鼠外周血清性激素水平的影响[J].湖南中医药大学学报,2018,38(8):866-869[点击复制] |
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| 仙子益真胶囊对卵巢早衰小鼠外周血清性激素水平的影响 |
| 黄晋琰,林夏静,徐珉 |
| (广州中医药大学第二附属医院妇科, 广东 广州 510120) |
| 摘要: |
| 目的 观察补肾填精中药仙子益真胶囊对卵巢早衰（premature ovarian failure，POF）模型小鼠性激素调节作用，初步探讨仙子益真胶囊治疗卵巢早衰的可能机制。方法 选用动情周期规律的SPF级雌性C57BL/6J性小鼠随机分为空白对照组、造模组。造模组使用雷公藤多苷片造模成功后，再随机分为模型组，益真低、中、高剂量组和西药组，并予以相应干预。治疗结束后ELISA测定血清中雌二醇（estradiol，E2）、卵泡刺激素（follicle-stimulating hormone，FSH）及黄体生成素（luteinizing hormone，LH）的含量。结果 与空白对照组比较，模型组E2含量下降，FSH、LH含量升高，差异有统计学意义（P<0.01）；与模型组比较，益真低剂量组、益真中剂量组、益真高剂量组、西药组E2含量上升，FSH、LH含量下降，差异有统计学意义（P<0.01）。结论 补肾填精中药仙子益真胶囊可以提高POF模型小鼠血清E2的含量，降低FSH、LH的含量，改善POF小鼠生殖内分泌环境。 |
| 关键词: 卵巢早衰 仙子益真胶囊 中医药疗法 性激素 |
| DOI：10.3969/j.issn.1674-070X.2018.08.006 |
| 投稿时间：2017-10-29 |
| 基金项目:国家中医药管理局课题（1199ws02）；广东省中医药局科研课题（20152133）。 |
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| Effect of Xianzi Yizhen Capsule on Peripheral Serum Sex Hormones in Mice with Premature Ovarian Failure |
| HUANG Jinyan,LIN Xiajing,XU Min |
| (Department of Gynecology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510120, China) |
| Abstract: |
| Objective To investigate the regulatory effect of Xianzi Yizhen Capsule, a Chinese patent drug for nourishing kidney-essence, on sex hormones in mice with premature ovarian failure(POF) and the possible mechanism of Xianzi Yizhen Capsule in the treatment of POF. Methods The specific pathogen-free female C57BL/6J mice with a regular estrous cycle were randomly divided into blank control group and model group. The mice in the model group were treated with Tripterygium wilfordii polyglycoside tablets to establish a mouse model of POF and were then randomly divided into model group, low-, middle-, and high-dose Yizhen groups, and Western medicine group, and corresponding treatment was given. After the treatment ended, ELISA was used to measure the serum level of estradiol (E2), follicle-stimulating hormone (FSH), and luteinizing hormone (LH). Results Compared with the blank control group, the model group had a significant reduction in E2 and significant increases in FSH and LH (P<0.01). Compared with the model group, the low-, middle-, and high-dose Yizhen groups and the Western medicine group had a significant increase in E2 and significant reductions in FSH and LH (P<0.01). Conclusion In mice with POF, the kidney essence-nourishing traditional Chinese medicine Xianzi Yizhen Capsule can improve the serum level of E2, reduce the serum levels of FSH and LH, and improve reproductive endocrine environment. |
| Key words: premature ovarian failure Xianzi Yizhen Capsule traditional Chinese medicine treatment sex hormone |
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