| 引用本文: |
魏歆然,魏高文,郑雪娜,吴雪芬,郭鑫,岳增辉.循经选穴针刺对失眠大鼠褪黑素的影响[J].湖南中医药大学学报,2018,38(7):787-790[点击复制] |
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| 循经选穴针刺对失眠大鼠褪黑素的影响 |
| 魏歆然,魏高文,郑雪娜,吴雪芬,郭鑫,岳增辉 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007;湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 目的 观察固定局部取穴（百会）分别配伍循经（本经、他经、非经）选穴针刺治疗对失眠大鼠生物褪黑素（MT）含量的影响，探索循经选穴对腧穴配伍效应的影响。方法 将60只SD雄性大鼠随机分为5组：空白组、模型组、本经穴组（百会+神门组）、他经穴组（百会+三阴交组）、非经非穴组（百会+非经非穴组），每组12只，用腹腔注射对氯苯丙氨酸法（PCPA，500 mg/kg）2 d建立失眠模型，针刺治疗7 d，用ELISA法检测下丘脑腹外侧视前区（VLPO）、视交叉上核（SCN）与血浆中的MT含量。结果 与空白组比较，模型组MT含量均降低（P<0.05）；与模型组比较，本经穴组、他经穴组MT含量升高（P<0.05）；治疗组之间比较，本经穴组高于非经非穴组（P<0.05）。结论 固定局部百会穴配伍本经选穴（神门）针刺治疗可以提高失眠大鼠的褪黑素含量，从而提高腧穴配伍效应。 |
| 关键词: 循经选穴 针刺 失眠 褪黑素 |
| DOI：10.3969/j.issn.1674-070X.2018.07.016 |
| 投稿时间：2018-02-17 |
| 基金项目:国家重点基础研究发展计划（973计划）项目（2014CB543102）。 |
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| Effect of Acupuncture with Acupoint Selection Along the Meridians on the Level of Melatonin in Rats with Insomnia |
| WEI Xinran,WEI Gaowen,ZHENG Xuena,WU Xuefen,GUO Xin,YUE Zenghui |
| (The First Affiliated Hospital of Hunan Universty of Chinese Medicine, Changsha, Hunan 410007, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To investigate the effect of acupuncture at Baihui acupoint combined with acupoint selection along the meridians (the same meridian, the related meridians, and non-meridians) on the level of melatonin (MT) in rats with insomnia and the effect of acupoint selection along the meridians on acupoint compatibility. Methods A total of 60 male Sprague-Dawley rats were randomly divided into blank group, model group, same meridian group (Baihui and Shenmen), related meridian group (Baihui and Sanyinjiao), and non-meridian/acupoint group (Baihui and non-meridians/acupoints), with 12 rats in each group. A model of insomnia was established by intraperitoneal injection of para-chlorophenylalanine (500 mg/kg) for 2 days, and acupuncture was performed for 7 days. ELISA was used to measure the content of MT in the ventral lateral preoptic area, the suprachiasmatic nucleus, and plasma. Results Compared with the blank group, the model group had a significant reduction in the content of MT (P<0.05); compared with the model group, the same meridian group and the related meridian group had a significant increase in the content of MT (P<0.05); the same meridian group had a significantly higher level of MT than the non-meridian/acupoint group (P<0.05). Conclusion Acupuncture at Baihui acupoint with acupoint selection along the same meridian (Shenmen) can increase the content of MT in rats with insomnia and improve acupoint compatibility. |
| Key words: acupoint selection along the meridians acupuncture insomnia melatonin |
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