| 引用本文: |
刘丹,谢枫枫,陈莹.香砂六君子汤对乳腺癌化疗患者的减毒及增效作用观察[J].湖南中医药大学学报,2018,38(4):455-458[点击复制] |
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| 香砂六君子汤对乳腺癌化疗患者的减毒及增效作用观察 |
| 刘丹,谢枫枫,陈莹 |
| (广东省中医院乳腺科, 广东 广州 510000) |
| 摘要: |
| 目的 观察香砂六君子汤用于乳腺癌化疗患者的减毒及增效作用。方法 选取120例乳腺癌患者，按随机数字表分为观察组与对照组，各60例。两组均于术前予以环磷酰胺联合表柔比星4周期序贯多西他赛4周期（EC×4-T×4）方案，观察组在对照组基础上服用香砂六君子汤。比较两组临床获益率（CBR），恶心呕吐、脱发、腹泻、白细胞计数减少、谷丙转氨酶水平升高等毒副反应，并比较两组治疗前后生活质量。结果 观察组CBR为96.7%，显著高于对照组86.7%（P<0.05）。两组化疗期间观察组恶心呕吐及白细胞计数减少的毒副反应分级较对照组显著减轻（P<0.05）。观察组治疗后生理状况、情感状况、FACT-G总分及FACT-B总分显著高于治疗前及对照组（P<0.05）。结论 香砂六君子汤在乳腺癌化疗患者中的应用可强化化疗疗效并减轻毒副反应，效果显著，值得推广。 |
| 关键词: 乳腺癌 化疗 香砂六君子汤 减毒 增效 临床观察 |
| DOI：10.3969/j.issn.1674-070X.2018.04.023 |
| 投稿时间：2017-12-15 |
| 基金项目:广东省医药管理局项目（201611922331972）。 |
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| Synergy and Attenuation Effects of Xiangsha Liujunzi Decoction on Breast Cancer Patients with Chemotherapy |
| LIU Dan,XIE Fengfeng,CHEN Ying |
| (Department of Breast Surgery, Guangdong Hospital of TCM, Guangzhou, Guangdong 510000, China) |
| Abstract: |
| Objective To observe the synergy and attenuation effect of Xiangsha Liujunzi decoction on cancer patients with chemotherapy. Methods A total of 120 cases of breast cancer patients were randomly divided into observation group and control group according to random number table, 60 cases in each group. The two groups were given cyclophosphamide combined with epirubicin 4 cycle sequential docetaxel 4 cycle (EC×4-T×4) scheme preoperatively. The observation group was given Xiangsha Liujunzi decoction on the basis of the control group. The toxic and side effects of the two groups, such as clinical benefit rate (CBR), nausea and vomiting, hair loss, diarrhea, reduced white blood cell count, elevated levels of alanine aminotransferase, were compared, and the quality of life before and after treatment was also compared between the two groups. Results The CBR of the observation group was 96.67%, which was significantly higher than 86.67% in control group (P<0.05). The grading of nausea and vomiting, reduced white blood cell count in the observation group was significantly lighter than those in control group (P<0.05). After treatment, the physiological status, emotional status, FACT-G total score and FACT-B score of the observation group were significantly higher than those of the control group (P<0.05). Conclusion Xiangsha Liujunzi decoction could significantly enhance the efficacy and reduce toxicity, worthy of promoting. |
| Key words: breast cancer chemotherapy Xiangsha Liujunzi decoction attenuation synergy clinical observation |
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