| 引用本文: |
杨磊,刘梦娇,吴萍,戴冰,张志国.基于肝毒性探讨何首乌临床合理应用[J].湖南中医药大学学报,2018,38(3):280-283[点击复制] |
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| 基于肝毒性探讨何首乌临床合理应用 |
| 杨磊,刘梦娇,吴萍,戴冰,张志国 |
| (湖南中医药大学第一附属医院, 全国名老中医药专家张志国传承工作室, 湖南 长沙 410007;湖南中医药大学, 湖南 长沙 410208;常德市第一人民医院, 湖南 常德 415700) |
| 摘要: |
| 目的 促进临床合理使用何首乌，降低肝毒性不良反应发生率。方法 通过查阅文献及相关实验数据分析，探索何首乌肝毒性发生的潜在因素，并针对因素提出临床合理使用建议和用药监护。结果 何首乌肝毒性的发生与炮制方法、炮制程度、化学成分、特异体质等因素有关，临床使用时应注重药品质量，辨证用药，对易感人群加强监护。结论 合理使用何首乌，可降低肝毒性不良反应发生率。 |
| 关键词: 何首乌 肝毒性 合理用药 |
| DOI：10.3969/j.issn.1674-070X.2018.03.012 |
| 投稿时间：2017-11-21 |
| 基金项目:湖南省自然科学基金（2017JJ3247）；湖南省发改委基金（[2016]518）。 |
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| Reasonable Clinical Application of Polygoni Multiflori Radix Based on Hepatotoxicity |
| YANG Lei,LIU Mengjiao,WU Ping,DAI Bing,ZHANG Zhiguo |
| (The First Affiliated Hospital of Hunan University of Chinese Medicine, Chinese Medicine Experts Zhang Zhiguo Heritage Studio, Changsha, Hunan 410007, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The First People's Hospital of Changde, Changde, Hunan 415700, China) |
| Abstract: |
| Objective To promote rational use of Polygoni Multiflori Radix (Heshouwu) in clinic, to reduce the incidence rate of adverse effects of hepatotoxicity. Methods The potential factors of hepatotoxicity in polygonum multiflorum thunb through consulting document and analysing related experimental data were explored, and then the reasonable clinical use suggestion and the medication guardianship according to the factors were put forward. Results The occurence of hepatotoxicity of Polygoni Multiflori Radix were related to these factors, such as processing method, processing degree, chemical constituents, idiosyncrasy. The quality of drugs, dialectical medication and intensive care for susceptical people should be paid more attention. Conclusion Rational use of Polygoni Multiflori Radix could reduce the incidence rate of hepatotoxicity adverse reactions. |
| Key words: Polygoni Multiflori Radix hepatotoxicity rational drug use |
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