| 引用本文: |
黄芳,蒋玉欢,郭飞波,郑志刚.银杏达莫注射液联合醋酸泼尼松治疗突发性耳聋患者疗效观察及其对患者血液流变学和细胞因子影响[J].湖南中医药大学学报,2018,38(1):85-88[点击复制] |
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| 银杏达莫注射液联合醋酸泼尼松治疗突发性耳聋患者疗效观察及其对患者血液流变学和细胞因子影响 |
| 黄芳,蒋玉欢,郭飞波,郑志刚 |
| (湖北省天门市第一人民医院耳鼻咽喉头颈外科, 湖北 天门 431700;湖北省天门市第一人民医院检验科, 湖北 天门 431700) |
| 摘要: |
| 目的 探讨突发性耳聋患者采用银杏达莫注射液联合醋酸泼尼松治疗的效果，观察患者治疗前后血液流变学及血清炎症细胞因子的变化情况。方法 纳入我院收治的突发性耳聋患者102例（102耳），随机分成对照组与观察组，每组各51例（51耳），对照组单纯采用醋酸泼尼松治疗，观察组在对照组基础上加用银杏达莫注射液。观察两组治疗效果，并采集血液样本测定血浆黏度（PV）、血细胞比容（HCT）、红细胞聚集指数（EAI）以及细胞因子中性粒细胞激活肽-78（ENA-78）、血清高迁移率蛋白-1（HMGB1）水平，记录治疗期间不良事件发生率。结果 观察组有效率为94.12%，高于对照组的76.47%，差异有统计学意义（P<0.05）；两组治疗1周的ENA-78低于治疗前，治疗2周后的ENA-78、HMGB1均低于治疗前；观察组治疗2周后的ENA-78、HMGB1均低于对照组，差异有统计学意义（P<0.05）；在治疗1周、2周后，两组各指标较治疗前均显著下降，其中观察组治疗2周的PV、HCT、EAI均低于同时段对照组，差异有统计学意义（P<0.01）。观察组不良事件发生率为5.88%，与对照组的1.96%比较差异无统计学意义（P>0.05）。结论 突发性耳聋患者采用银杏达莫注射液联合醋酸泼尼松治疗，能进一步改善血液流变学以及趋化因子水平，疗效显著，用药安全，值得临床推广。 |
| 关键词: 突发性耳聋 银杏达莫注射液 醋酸泼尼松 |
| DOI：10.3969/j.issn.1674-070X.2017.01.022 |
| 投稿时间：2017-10-26 |
| 基金项目:湖北省医学科技攻关计划项目（201403209）。 |
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| Clinical Effect of Ginkgo-Damole Injection Combined with Prednisone Acetate on Hemorheology and Cytokines in Patients with Sudden Deafness |
| HUANG Fang,JIANG Yuhuan,GUO Feibo,ZHENG Zhigang |
| (Department of Otorhinolaryngology Head and Neck Surgery, the First People's Hospital, Tianmen, Hubei 431700, China;Department of Laboratory, Tianmen First People's Hospital, Tianmen, Hubei 431700, China) |
| Abstract: |
| Objective To explore the effect of ginkgo-damole injection combined with prednisone acetate in treatment of patients with sudden deafness,hemorheology and serum inflammatory cytokines of patients before and after treatment were observed.Methods 102 cases of patients (102 eyes) with sudden deafness were randomly divided into the control group and observation group,51 cases (51 eyes) in each group.The control group was treated with acetic acid prednisone,the observation group was given with ginkgo biloba injection on the basis of the control group.Therapeutic effect of the two groups was observed.The plasma viscosity (PV),hematocrit (HCT),erythrocyte aggregation index (EAI) and cytokines neutrophil activation peptide (ENA-78),the high mobility of serum protein 1(HMGB1) levels and the incidence of adverse events during treatment were recorded.Results The effective rate of observation group was 94.12%,higher than 76.47% in the control group,and the difference was statistically significant (P<0.05).After treatment for one week,ENA-78 of two groups was lower than before treatment;ENA-78,HMGB after treatment for two weeks were lower than before treatment,and the observation group was lower than control group (P<0.05).The indicators of the two groups after treatment for one week and two weeks decreased siginificantly,and after treatment for two weeks,PV,HCT,EAI of observation group were lower than the control group,the difference was statistically significant (P<0.01).The incidence of adverse events in the observation group was 5.88%,compared with 1.96% in the control group (P>0.05).Conclusion Ginkgo-damole injection combined with prednisone acetate could improve the blood rheology and chemokine levels of patients with sudden deafness.It is worth clinical promotion. |
| Key words: sudden deafness ginkgo-damole injection prednisone acetate |
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