| 引用本文: |
项宇,刘家琪,李萍,彭俊,刘晓清,汤杰,喻娟,龙达,彭清华.青光安颗粒剂对自发型青光眼小鼠眼压的影响[J].湖南中医药大学学报,2018,38(1):17-20[点击复制] |
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| 青光安颗粒剂对自发型青光眼小鼠眼压的影响 |
| 项宇,刘家琪,李萍,彭俊,刘晓清,汤杰,喻娟,龙达,彭清华 |
| (湖南中医药大学第一附属医院中医眼科学重点学科, 湖南 长沙 410007) |
| 摘要: |
| 目的 研究青光安颗粒剂在青光眼中对眼压的影响。方法 选用不同月龄共30只DBA/2J雌性小鼠，根据月龄采用随机数字表法分为3组，每组10只，20眼。分为正常对照组（3月龄）、模型对照组（9月龄）、青光安组（9月龄）。正常对照组与模型对照组每日以相同量蒸馏水灌胃；青光安组每日以青光安灌胃。3组均以常规饲料喂养。利用经前房注入/抽吸系统进行眼压测量，分别以2.5、5 μL/min的速率继续进行灌注，计算房水流畅系数和房水流出阻力。结果 自6月龄开始，小鼠眼压轻微上升，随着月龄的增加而逐步上升，9月龄时显著升高；青光安颗粒剂灌胃后所得眼压较模型组均有不同程度降低（P<0.05），房水流畅系数均明显增加（P<0.01），房水流出阻力均降低（P<0.01）。结论 青光安颗粒剂能通过影响房水动力学因素达到降低青光眼眼压的作用。 |
| 关键词: 青光安 青光眼 眼压 房水动力学 |
| DOI：10.3969/j.issn.1674-070X.2017.01.005 |
| 投稿时间：2017-06-15 |
| 基金项目:国家自然科学基金资助项目（81403437，81603665）；湖南省高层次卫生人才“225”工程培养项目资助；中国博士后基金面上资助项目（2015M570681）；湖南省自然科学基金资助项目（2015JJ3097）；湖南省教育厅科研基金优秀青年资助项目（14B137）；湖南省研究生创新基金重点资助项目（CX2013A013）；国家中医药管理局中医眼科学重点学科建设项目；湖南省中医五官科学重点学科建设项目。 |
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| Effect of Qingguangan Granules on Intraocular Pressure of Spontaneous Glaucoma Mice |
| XIANG Yu,LIU Jiaqi,LI Ping,PENG Jun,LIU Xiaoqing,TANG Jie,YU Juan,LONG Da,PENG Qinghua |
| (The Key Disciplines of Phthalmology of Traditional Chinese Medicine, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective Effect of Qingguangan Granule on intraocular pressure in glaucoma.Methods Thirty female DBA/2J mice were selected.The mice were randomly divided into three groups,the normal control group (three months old),model control group (nine months old),Qingguangan group (nine months old),10 rats with 20 eyes in each group.The control group and model group were given same distilled water by gavage,and Qingguangan group was given Qingguangan granules.The three groups were administrated with conventional feed with the rate of 2.5 and 5 μL/min.The intraocular pressure was measured by anterior chamber injection/suction system,and the coefficient of aqueous outflow and outflow resistance were measured.Results The intraocular pressure of mice at six months olds increased slightly,and gradually increased with the increase of the months old,and increased significantly at nine months old (P<0.05).The intraocular pressure decreased in different degree compared with the model group after intragastric administration of Qingguangan granules (P<0.01).The coefficient of aqueous humor increased significantly and outflow resistance decreased (P<0.01).Conclusion Qingguangan Granules can reduce glaucoma intraocular pressure through affecting aqueous humor dynamics. |
| Key words: Qingguangan granules glaucoma intraocular pressure aqueous humor dynamics |
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