| 引用本文: |
马荣丽,李勇敏,谭小宁,罗吉,吕元,罗燕.肾细胞外泌体的研究进展[J].湖南中医药大学学报,2017,37(11):1291-1294[点击复制] |
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| 肾细胞外泌体的研究进展 |
| 马荣丽,李勇敏,谭小宁,罗吉,吕元,罗燕 |
| (湖南省中医药研究院附属医院, 湖南 长沙 410006) |
| 摘要: |
| 外泌体（Exosomes）是一种细胞分泌的，携带大量活性物质，传递细胞间通信的纳米囊泡。肾细胞外泌体参与肾脏再生、修复及肾小管细胞间交流，调控骨细胞生长，在肾病的进展、控制及肾肿瘤中扮演重要角色，有作为肾脏疾病靶向治疗剂的潜力。尿液外泌体含有慢性肾病、糖尿病肾病、肾纤维化及肾肿瘤等潜在的标志物。肾脏作为机体重要器官，其外泌体（包括尿外泌体）的研究方兴未艾，现对其研究进展做一总结。 |
| 关键词: 肾细胞外泌体 生物学功能 标志物 分子学诊断 靶向治疗 |
| DOI：10.3969/j.issn.1674-070X.2017.11.030 |
| 投稿时间：2016-07-27 |
| 基金项目:国家自然科学基金面上项目（81774163）；湖南省研究生科研创新项目（CX2016B374）。 |
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| Research Progress of the Renal Cell Exosomes |
| MA Rongli,LI Yongmin,TAN Xiaoning,LUO Ji,LV Yuan,LUO Yan |
| (The Affiliated Hospital of Hunan Academy of Chinese Medicine, Changsha, Hunan 410006, China) |
| Abstract: |
| Exosomes are small-sized nanovesicles secreted by cells,which carries a large number of active substances and transfers intercellular communication. Renal cell exosomes has the potential as a therapeutic agent for kidney disease, which are involved in kidney regeneration, repair and communication between renal tubule cells, regulating the growth of bone cells, plays an important role in the progression and control of kidney disease. Urinary exosomes contain potential markers such as chronic kidney disease, diabetic nephropathy, renal fibrosis, and kidney tumors. The research progress of exosomes (including urinary exosomes) of kidney, as an important organ, is summarized in this paper. |
| Key words: renal cell exosomes biological functions biomarker molecular diagnostics targeted therapy |
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