| 引用本文: |
梁嘉樑,孙军锁,景斗星,杨楠.散寒镇痛方贴敷联合硫酸氨基葡萄糖片治疗寒湿阻络型膝关节骨性关节炎的临床研究[J].湖南中医药大学学报,2017,37(11):1265-1268[点击复制] |
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| 散寒镇痛方贴敷联合硫酸氨基葡萄糖片治疗寒湿阻络型膝关节骨性关节炎的临床研究 |
| 梁嘉樑,孙军锁,景斗星,杨楠 |
| (陕西省宝鸡市中医医院手足显微骨科, 陕西 宝鸡 721000) |
| 摘要: |
| 目的 探讨自拟散寒镇痛方穴位贴敷辅助硫酸氨基葡萄糖治疗寒湿阻络型膝关节骨性关节炎临床疗效。方法 研究对象选取本院2014年4月-2015年4月收治寒湿阻络型膝关节骨性关节炎患者共140例，以随机法抽签分为对照组（70例）和治疗组（70例），分别给予硫酸氨基葡萄糖单用和在此基础上加用自拟散寒镇痛方穴位贴敷辅助治疗，比较两组患者近期疗效，治疗前后VAS评分、WOMAC评分、SF-36评分、实验室指标水平及随访复发率等。结果 治疗组患者近期疗效显著优于对照组（P<0.05）；治疗组患者治疗后VAS评分和WOMAC评分均显著低于对照组、治疗前（P<0.01）；治疗组患者治疗后SF-36评分显著高于对照组、治疗前（P<0.01）；同时治疗组患者治疗后膝关节液SDF-1、MMP1及MMP3水平均显著低于对照组、治疗前（P<0.01）；治疗组患者远期复发率显著低于对照组（P<0.05）。结论 自拟散寒镇痛方穴位贴敷辅助硫酸氨基葡萄糖治疗寒湿阻络型膝关节骨性关节炎可显著缓解关节疼痛症状，促进关节正常活动功能恢复，改善日常生活质量，下调SDF-1、MMP1及MMP3水平，并有助于避免远期复发。 |
| 关键词: 膝关节骨性关节炎 寒湿阻络型 散寒镇痛方 穴位贴敷 硫酸氨基葡萄糖片 |
| DOI：10.3969/j.issn.1674-070X.2017.11.023 |
| 投稿时间：2016-07-27 |
| 基金项目: |
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| Clinical Study of Applying Self-made Sanhan Zhentong Decoction Combined with Glucosamine Sulfate Tablet in Treatment of Knee Osteoarthritis with Cold-Damp in Collaterals Syndrome |
| LIANG Jialiang,SUN Junsuo,JING Douxing,YANG Nan |
| (Micro Orthopedics Department of Hand and Foot, Baoji Hospital of Traditional Chinese Medicine, Baoji, Shaanxi 721000, China) |
| Abstract: |
| Objective To investigate the clinical effects of applying self-made Sanhan Zhentong decoction combined with glucosamine sulfate tablet in the treatment of knee osteoarthritis with cold-damp in collaterals (Hanshi Zuluo) syndrome. Methods 140 patients with Hanshi Zuluo type knee osteoarthritis were selected in the period from April 2014 to April 2015 in our hospital and randomly divided into both groups including control group (70 patients) with glucosamine sulfate used alone and treatment group (70 patients) with self-made Sanhan Zhentong decoction on the basis of control group. The clinical efficacy, the VAS score, WOMAC score, SF-36 score and laboratory index levels of knee joint before and after treatment and the recurrence rate with follow-up of both groups were compared. Results The clinical efficacy of treatment group was significantly better than control group (P<0.05). The VAS score and WOMAC score after operation of treatment group were significantly lower than control group and before treatment (P<0.05). The SF-36 score after operation of treatment group was significantly higher than control group and before treatment (P<0.05). The SDF-1, MMP-1 and MMP3 level of knee joint of treatment group were significantly lower than control group and before treatment(P<0.05). The recurrence rate with follow-up of treatment group was significantly better than control group (P<0.05). Conclusion Self-made Sanhan Zhentong decoction combined with glucosamine sulfate tablet in treatment of Hanshi Zuluo type knee osteoarthritis can efficiently relieve the symptoms of joint pain, promote the recovery process of normal activities of joint function, improve the quality of daily life, lower the levels of SDF-1, MMP1 and MMP3, and are helpful to avoid the recurrence for long-term. |
| Key words: knee osteoarthritis cold-damp in collaterals type Sanhan Zhentong decoction acupoint application glucosamine sulfate tablet |
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