| 引用本文: |
齐堃,张彧,杨仁义,吴东升,龙雨,唐慧新,罗尧岳.中医方药调控肾纤维化相关信号通路的研究进展[J].湖南中医药大学学报,2017,37(9):1044-1048[点击复制] |
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| 中医方药调控肾纤维化相关信号通路的研究进展 |
| 齐堃,张彧,杨仁义,吴东升,龙雨,唐慧新,罗尧岳 |
| (湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 肾纤维化相关研究的信号转导通路包括TGF-β1/Smad通路、Wnt/β-catenin信号通路、mTOR信号通路、Sonic Hedgehog通路、ERK1/2通路、P38 MAPK信号通路和HGF/c-met信号通路等。大量实验研究表明，中医方药可通过多环节、多途径、多靶点调节相关信号通路的表达，干预肾纤维化进程。基于此，本文就中医药干预肾纤维化相关信号通路研究进展进行综述，以期为中医药防治肾纤维化疾病提供循证依据。 |
| 关键词: 肾纤维化 中草药 中药复方 信号通路 |
| DOI：10.3969/j.issn.1674-070X.2017.09.029 |
| 投稿时间：2016-12-13 |
| 基金项目:湖南中医药大学大学生创新性课题研究（1022-0001019）； 湖南省教育厅科学研究重点项目（15A144）；教育部博士点科研基金（20134323120007）。 |
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| Research Progress of Related Signaling Pathways of Renal Fibrosis Syndromes Regulated by Traditional Chinese Medicine |
| QI Kun,ZHANG Yu,YANG Renyi,WU Dongsheng,LONG Yu,TANG Huixin,LUO Yaoyue |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Renal fibrosis related signal transduction pathways include TGF-β 1/Smad pathway, Wnt/β-catenin signaling pathway, mTOR signaling pathways, Sonic Hedgehog pathway, ERK 1/2 pathway, P38 lightning MAPK signaling pathway and HGF/c-met signaling pathway, etc. A large number of studies showed that prescriptions of traditinal Chinese medicine could intervene the process of renal fibrosis by regulating the expression of signaling pathways through multi-link, multi-way, multi-targets. The research progress of TCM intervention in renal fibrosis related signaling pathways were reviewed to provide some scientific evidences for the prevention and treatment of renal fibrosis disease with traditional Chinese medicine. |
| Key words: renal fibrosis traditional Chinese medicine Chinese herbal compound signaling pathway |
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