| 引用本文: |
杨仁义,吴佳敏,侯一楠,曾丽红,唐慧新,李玲.PM2.5对心血管系统的影响及中医药防治[J].湖南中医药大学学报,2017,37(9):1036-1040[点击复制] |
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| PM2.5对心血管系统的影响及中医药防治 |
| 杨仁义,吴佳敏,侯一楠,曾丽红,唐慧新,李玲 |
| (湖南中医药大学中西医结合学院, 湖南 长沙 410208;湖南中医药大学中医学院, 湖南 长沙 410208) |
| 摘要: |
| PM2.5（空气动力学等效直径Dp≤2.5 μm）是大气颗粒物的主要组成成分和主要毒性成分，大量研究结果发现，PM2.5能直接或间接影响心血管系统，其中氧化应激、炎症是主要的致病机制。本文综述PM2.5通过氧化应激与炎症反应相关途径对内皮细胞的损伤、细胞程序化死亡的研究进展以及中医药防治的相关研究，并提出PM2.5对心血管系统的影响可能与血管内皮细胞焦亡性损伤有关。 |
| 关键词: PM2.5 氧化应激 炎症 细胞焦亡 细胞自噬 细胞凋亡 中医药 |
| DOI：10.3969/j.issn.1674-070X.2017.09.027 |
| 投稿时间：2017-02-08 |
| 基金项目:湖南省大学生研究性学习和创新性实验计划项目（2016-209）。 |
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| Effects of PM2.5 on Cardiovascular System and its Prevention and Treatment with Traditional Chinese Medicine |
| YANG Renyi,WU Jiamin,HOU Yi'nan,ZENG Lihong,TANG Huixin,LI Ling |
| (College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| PM2.5 (aerodynamicale quivalent diameter, Dp≤2.5 μm) is the main component of atmospheric particulates. A large number of researches suggest that PM2.5 could affect cardiovascular system directly or indirectly, while oxidative stress reaction and inflammation reaction are the main pathogenic mechanisms. The research progress of PM2.5 on pyroptosis and the damage of endothelial cell by related pathways of oxidative stress and inflammation reaction, and its prevention and treatment with traditional Chinese medicine were reviewed. All results suggest that pyroptosis of vascular endothelial cell may be related with the cardiovascular system diseases caused by PM2.5. |
| Key words: PM2.5 oxidative stress inflammation pyroptosis autophagy traditional Chinese medicine |
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