| 引用本文: |
马小勇,席蓉蓉,房荣.复方鳖甲软肝片辅助治疗慢性丙型肝炎纤维化疗效观察[J].湖南中医药大学学报,2017,37(8):887-890[点击复制] |
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| 复方鳖甲软肝片辅助治疗慢性丙型肝炎纤维化疗效观察 |
| 马小勇,席蓉蓉,房荣 |
| (延安市人民医院感染科, 陕西 延安 716000) |
| 摘要: |
| 目的 观察复方鳖甲软肝片辅助治疗慢性丙型肝炎纤维化的疗效。方法 将56例慢性丙肝患者随机分为观察组与对照组各28例，观察组采用复方鳖甲软肝片联合聚乙二醇干扰素ɑ-2b（PegIFNɑ-2b）及利巴韦林治疗，对照组采用PegIFNɑ-2b及利巴韦林进行治疗，疗程24周，持续2个疗程。观察比较2组患者的病毒学应答、肝脏瞬时弹性成像，检查测定肝脏硬度值（LSM）、治疗前后血清丙氨酸氨基转氨酶（ALT）及透明质酸（HA）、层粘连蛋白（LN）、Ⅲ型前胶原（PC-Ⅲ）、Ⅳ型胶原（Ⅳ-C）、血清肿瘤坏死因子α（TNF-α）、转化生长因子-β1（TGF-β1）、白介素6（IL-6）的变化。结果 观察组患者获得持续病毒应答（SVR）20例，对照组18例，组间比较差异无统计学意义（P> 0.05）；两组LSM较治疗前均降低，观察组LSM显著低于对照组（P< 0.05）；治疗后观察组ALT、HA、LN、PC-III、IV-C、TNF-α、TGF-β1、IL-6较治疗前显著降低，差异有统计学意义（P< 0.05），观察组治疗效果优于对照组，差异有统计学意义（P< 0.05）。结论 复方鳖甲软肝片可显著改善慢性丙型肝炎肝纤维化程度，起到辅助治疗的作用。 |
| 关键词: 慢性丙型肝炎 复方鳖甲软肝片 肝纤维化 利巴韦林 肝脏瞬时弹性 病毒学应答 |
| DOI：10.3969/j.issn.1674-070X.2017.08.018 |
| 投稿时间：2016-08-08 |
| 基金项目:陕西省科技计划项目（2015K13-1-071-63）。 |
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| Effect of Fufang Biejia Ruangan Tablet on Liver Fibrosis in Chronic Hepatitis C |
| MA Xiaoyong,XI Rongrong,FANG Rong |
| (Infectious Department, Yan'an City People's Hospital, Yan'an, Shangxi 716000, China) |
| Abstract: |
| Objective To observe the curative effect of Fufang Biejia Ruangan tablet on adjuvant therapy of liver fibrosis in chronic hepatitis C. Methods Totally 56 selected CHC patients were randomly divided into the observation group and control group, 28 cases in each group. Control group was given PegIFNα-2b subcutaneous injection and ribavirin orally each time. Observation group was treated wih Fufang Biejia Ruangan tablet on the basis of control group. The treatment course was for 24 weeks, which lasted for two courses. The virological response and liver transient elastography in two groups were determined. The liver stiffness values examination (LSM), serum alanine aminotransferase (ALT), hyaluronic acid (HA), laminin (LN), procollagen III (PC-III), type IV collagen (IV-C), serum tumor necrosis factor alpha (TNF-α) and transforming growth factor beta 1 (TGF-β1) and interleukin 6 (IL-6) were tested. Results 20 patients in observation group and 18 cases in control group received SVR, there is no significant difference between two groups (P> 0.05). LSM of the two groups were lower than before treatment, LSM in observation group was significantly lower than the control group (P<0.05). After treatment, ALT, HA, LN, PC-III, IV-C, TNF-α, TGF-β1, IL-6 in observation group were significantly lower than that before treatment, the difference was statistically significant (P<0.05), the effect of the observation group was better than the control group, the difference was statistically significant (P<0.05). Conclusion Fufang Biejia Ruangan tablet could significantly improve the degree of liver fibrosis in chronic hepatitis C, it play the role of adjuvant therapy. |
| Key words: chronic hepatitis C Fufang Biejia Ruangan tablet liver fibrosis ribavirin hepatic transient elasticity virological response |
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