| 引用本文: |
谢胜军,梁慧,李晓萍,李伟,曾伟,尚姣.健脾理气、祛湿化瘀解毒法治疗晚期结直肠癌临床研究[J].湖南中医药大学学报,2017,37(2):196-199[点击复制] |
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| 健脾理气、祛湿化瘀解毒法治疗晚期结直肠癌临床研究 |
| 谢胜军,梁慧,李晓萍,李伟,曾伟,尚姣 |
| (湖南省肿瘤医院 中南大学湘雅医学院附属肿瘤医院, 湖南 长沙 410006) |
| 摘要: |
| 目的 评估健脾理气、祛湿化瘀解毒法治疗晚期结直肠癌的临床疗效。方法 将80例晚期结直肠癌患者随机分为中药组和对照组，每组各40例，中药组予以健脾理气、祛湿化瘀解毒中药，同时给予必要对症治疗，对照组给予单纯最佳支持治疗（BSC），观察两组临床症状、生存质量（KPS）、免疫指标、心电图、血常规及肝肾功能的变化情况，并随访患者疾病进展时间（TTP）。结果 在改善临床症状方面中药组治疗后较治疗前症状积分降低，前后比较有统计学意义（P<0.05），治疗后两组比较，中药组显著优于对照组（P<0.05）；在提高生存质量（KPS）方面，中药组治疗后较治疗前KPS评分升高，前后比较有统计学意义（P<0.05），治疗后中药组生存质量优于对照组有统计意义（P<0.05）；在免疫指标方面，中药组治疗后NK细胞活性及CD4/CD8比值均上升，前后比较有显著统计学意义（P<0.05），治疗后中药组免疫指标提高较对照组有统计意义（P<0.05）；治疗前后两组心电图、血常规、肝肾功能无明显变化；在疾病进展时间方面，中药组的TTP为6个月，对照组TTP为3个月，中药组TTP较对照组延长3个月，两组比较有显著统计学意义（P<0.05）。结论 健脾理气、祛湿化瘀解毒法治疗晚期结直肠癌患者在改善临床症状、提高生存质量和免疫力、延长无疾病进展时间等方面都具有较好的疗效。 |
| 关键词: 晚期结直肠癌 疾病进展时间 健脾理气 祛湿化瘀解毒 |
| DOI：10.3969/j.issn.1674-070X.2017.02.022 |
| 投稿时间：2016-01-10 |
| 基金项目:湖南省中医药管理局项目（2012140）；中南大学湘雅临床大数据系统项目。 |
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| Clinical Research of Jianpi Liqi and Qushi Huayu Jiedu Methods on Advanced Colorectal Cancer |
| XIE Shengjun,LIANG Hui,LI Xiaoping,LI Wei,ZENG Wei,SHANG Jiao |
| (Hunan Cancer Hospital, the Affiliated Cancer Hospital of Xingya School of Medicine, Central South University, Changsha, Hunan 410006, China) |
| Abstract: |
| Objective To evaluate the clinical efficacy of Jianpi Liqi and Qushi Huayu Jiedu methods on late colorectal cancer. Methods The 80 patients with advanced colorectal cancer were randomly divided into the Chinese medicine group and control groups, 40 cases in each group. The Chinese medicine group was given Jianpi Liqi and Qushi Huayu Jiedu therapy, while giving necessary symptomatic treatment. The control group was given the best supportive care (BSC). The changes of clinical symptoms, quality of life (KPS), immune parameters, ECG, blood routine and liver and kidney function were observed, and time to progression (TTP) of patients was also observed. Results In the improvement of clinical symptoms, the symptom score of Chinese medicine group after treatment was lower than before treatment, the comparison before and after treatment was statistically significant (P<0.05), the Chinese medicine group was significantly better than the control group after treatment (P<0.05). In the improvement of KPS, the KPS score in Chinese medicine group after treatment was higher than that before treatment, the comparison before and after treatment was statistically significant (P<0.05), the KBS of Chinese medicine group was significantly better than the control group after treatment (P<0.05). In the immune indicators, the NK cell activity and CD4/CD8 ratio of Chinese medicine group were increased after treatment, there was a statistical significance before and after treatment (P<0.05), the immune parameters of Chinese medicine group was superior to the control group (P<0.05). The electrocardiogram, blood routine, liver and kidney function have no significant changes. In the TTP, the Chinese medicine group was for six months, the control group was for three months, the TTP of Chinese medicine group extended three months than the control group, there was a significant statistical difference between the two groups (P<0.05). Conclusion Jianpi Liqi and Qushi Huayu Jiedu methods show good effect in improving clinical symptoms, KPS, immune parameters, TTP etc. of advanced colorectal cancer patients. |
| Key words: advanced colorectal cancer time to progression Jianpi Liqi(spleen-nourishing and Qi-regulating) Qushi Huayu Jiedu (expelling damp, removing blood stasis and detoxification) |
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