| 引用本文: |
郭格,顾锡镇.黄连温胆汤加减治疗失眠的Meta分析[J].湖南中医药大学学报,2017,37(1):83-86[点击复制] |
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| 黄连温胆汤加减治疗失眠的Meta分析 |
| 郭格,顾锡镇 |
| (南京中医药大学, 江苏 南京 210029;江苏省中医院, 江苏 南京 210029) |
| 摘要: |
| 目的 评价黄连温胆汤加减治疗失眠的临床疗效及安全性。方法 采用文献系统评价定性研究与定量Meta分析相结合的方法与技术，检索国内有关黄连温胆汤加减治疗失眠的临床随机对照试验，包括中国知网数据库、维普期刊全文数据库、万方数据库、中国生物医学文献数据库，依据所定纳入标准及排除标准对所检索的文献进行筛选，提取有效数据，运用RenMan 5.3软件对文献进行Meta分析。结果 最终纳入16篇随机对照试验，合计1511例患者。Meta分析显示，黄连温胆汤加减治疗失眠的临床总有效率高于西药治疗组（OR=3.61，95% CI[2.68，4.85]，P<0.00001）。结论 本次系统评价显示黄连温胆汤加减治疗失眠总有效率高于西药治疗组，安全性较高。但是所纳入的研究质量普遍偏低，需要高质量的随机对照试验进行验证。 |
| 关键词: 失眠 黄连温胆汤加减 疗效及安全性 Meta分析 |
| DOI：10.3969/j.issn.1674-070X.2017.01.021 |
| 投稿时间：2016-09-01 |
| 基金项目:2016江苏省名老中医药专家传承工作室建设项目；苏中医科教[2016]6号。 |
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| Meta Analysis of Modified Huanglian Wendan Decoction in Treating Insomnia |
| Guo Ge,GU Xizhen |
| (Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China;Jiangsu Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China) |
| Abstract: |
| Objective To evaluate the efficacy and safty of modified Huanglian Wendan Decoction in treating insomnia. Methods According to the systematic review principles and meta-analysis, we have researched randomized controlled clinical trials of Huanglian Wendan decoction in treatment of insomnia, including China National Knowledge Internet, VIP CNKI, Wanfang database, Chinese Biomedical Literature Database. The papers were screened based on predetermined inclusion criteria and exclusion criteria, and conducted meta-analysis by using RevMan 5.3 software. Results Finally 16 randomized controlled clinical trials, 1511 patients were included. Meta-analysis shows that the total effective rate of modified Huanglian Wendan decoction on treatment of insomnia was higher than that in Western medicine group (OR=3.61, 95%CI[2.68, 4.85], P<0.00001). Conclusion The systematic review shows that the total effective rate of Huanglian Wendan decoction on treatment of insomnia is higher than that in Western medicine group, with higher safty. However, the included studies were with poor quality, the results need high quality randomized controlled trials to verify. |
| Key words: insomnia modified Huanglian Wendan decoction efficacy and safty Meta-analysis |
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