| 引用本文: |
李成银,易宗毕,李俊娇,赵井苓,王琦苑.健脾益肾法治疗化疗后白细胞减少症的Meta分析[J].湖南中医药大学学报,2016,36(10):91-95[点击复制] |
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| 健脾益肾法治疗化疗后白细胞减少症的Meta分析 |
| 李成银,易宗毕,李俊娇,赵井苓,王琦苑 |
| (湖北省中医院, 湖北 武汉 430061;中国医学科学院北京协和医学院肿瘤医院, 北京100021;湖北中医药大学, 湖北 武汉 430065) |
| 摘要: |
| 目的 评价中药健脾益肾法治疗化疗后白细胞减少症的疗效及安全性。方法 计算机检索重庆维普全文数据库、中国知网、万方数据库、SinoMed中国生物医学文献数据库、PubmMed、Web of Science、EMBASE中关于中药健脾益肾法治疗化疗后白细胞减少症的临床研究文献，检索日期2000年1月至2016年5月。利用revman5.2、stata11软件进行Meta分析。结果 共纳入24篇随机对照试验，合计2369例患者。Meta分析显示，中药健脾益肾法治疗化疗后白细胞减少症在总有效率（RR=1.28，95% CI[1.18，1.39]，Z=5.73，P<0.001）与显效率（RR=1.65，95% CI[1.36，1.99]，Z=5.11，P<0.001）方面均高于常规服用升白细胞药物组。结论 采用中药健脾益肾法治疗化疗后白细胞减少症的总有效率和显效率明显高于常规服用升白药物组，但证据质量不高，仍需要更多大样本、多中心、高质量的随机对照试验进行验证。 |
| 关键词: 白细胞减少症 中医药疗法 健脾益肾 化疗 Meta分析 |
| DOI：10.3969/j.issn.1674-070X.2016.10.023 |
| 投稿时间：2016-04-19 |
| 基金项目: |
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| Meta Analysis of Spleen-invigorating and Kidney-tonifying Method in the Treatment of Leukopenia after Tumor Chemotherapy |
| LI Chengyin,YI Zongbi,LI Junjiao,ZHAO Jingling,WANG Qiyuan |
| (Hubei Hospital of TCM, Wuhan, Hubei 430061, China;Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;Hubei University of Chinese Medicine, Wuhan, Hubei 430065, China) |
| Abstract: |
| Objective To evaluate effectiveness and safety of spleen-invigorating and kindney-tonifying method in the treatment of leukopenia after tumor chemotherapy.Methods The papers on spleen-invigorating and kindney-tonifying method in the treatment of leukopenia after tumor chemotherapy,published in databases of VIP,CNKI,SinoMed,WANGFANG DATA,Web of Science,EMBASE from January 2000 to May 2016,were searched and Meta analysis was performed on the data by revman 5.2 software and stata11.Results Totally 24 RCT involving 2369 cases were included.The meta analysis results showed that the total effectiveness (RR=1.28,95% CI[1.18,1.39],Z=5.73,P<0.001) and significant effectiveness (RR=1.65,95% CI[1.36,1.99],Z=5.11,P<0.001) by spleen-invigorating and kindney-tonifying method were higher than that with nomal oral drugs for rising leukocyte in the treatment of leukopenia after tumor chemotherapy.Conclusion The spleen-invigorating and kindney-tonifying method in the treatment of leukopenia after tumor chemotherapy is superior to normal oral drugs in effectiveness.However,the above conclusion should be further confirmed by conducting more large-scale and well-designed RCTs due to the limited quantity and quality of the included studies. |
| Key words: leukopenia therapy of traditional Chinese medicine spleen-invigorating and kidney-tonifying chemotherapy Meta analysis |
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