| 引用本文: |
朱闽,何清湖.中医药通过调节Th17细胞分化在自身免疫性炎症性疾病中作用的研究进展[J].湖南中医药大学学报,2016,36(8):82-86[点击复制] |
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| 中医药通过调节Th17细胞分化在自身免疫性炎症性疾病中作用的研究进展 |
| 朱闽,何清湖 |
| (湖南中医药大学, 湖南 长沙 410208;广西中医药大学附属瑞康医院男性科, 广西 南宁 530011) |
| 摘要: |
| 辅助性T淋巴细胞17（T helper 17，Th17）与多种炎症性疾病、自身免疫性疾病及肿瘤密切相关。在自身免疫性炎症性疾病中大多存在偏向Th17一侧的分化失衡，Th17细胞的分化程度往往决定了炎症程度及持续时间。中医药在治疗炎症性疾病方面积累了丰富的经验，具有一定的优势和潜力，许多中药及中药复方被证实有明显的免疫调节及抗炎作用。本文就Th17细胞的分化调节及中医药在类风湿性关节炎、溃疡性结肠炎、强直性脊柱炎及慢性前列腺炎等疾病中对Th17细胞的调节作用研究进展进行综述。 |
| 关键词: 中医药 自身免疫性 炎症性 辅助性T淋巴细胞17 免疫调节 综述 |
| DOI：10.3969/j.issn.1674-070X.2016.08.023 |
| 投稿时间：2015-12-28 |
| 基金项目:广西自然科学基金面上项目（2013GXNSFAA019108）；广西自然科学基金面上项目（2014GXNSFAA118237）；广西卫生厅中医药科技专项（GZPT1227）；广西卫生厅中医药科技专项（GZLC14-16）。 |
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| The Review of Effects of Tranditional Chinese Medicine on Autoimmune Inflammatory Diseases by Regulating the Differentiation of Th17 Cell |
| ZHU Min,HE Qinghu |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Andrology Department in Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, 530011, China) |
| Abstract: |
| T helper 17(Th17) are closely related to multiple inflammatory diseases,autoimmune diseases and cancer.The differentiation imbalances biasing Th17 are found in most autoimmune inflammatory diseases.The differentiation of Th17 often determines the degree and the duration of inflammation.In the treatment of inflammatory,Traditional Chinese Medicine,which has accumulated rich experience,has a large advantage and potential.Many single herb and traditional Chinese medicine compound are proved having obvious effect of immunological regulation and inflammatory inhibition.We made a review of differentiated regulation of Th17 and regulating effect's research advance of traditional Chinese medicine in the treatment of rheumatoid arthritis,ulcerative colitis,ankylosing spondylitis,chronic prostatitis and other diseases. |
| Key words: traditional Chinese medicine autoimmunity inflammatory T helper 17 immunological regulation review |
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