| 引用本文: |
刘莎莎,艾启迪,陈乃宏.补益类中药抗衰老活性成分研究概况[J].湖南中医药大学学报,2016,36(4):74-78,86[点击复制] |
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| 补益类中药抗衰老活性成分研究概况 |
| 刘莎莎,艾启迪,陈乃宏 |
| (湘潭市中心医院, 湖南 湘潭 411100;中国医学科学院协和医学院神经科学中心药物研究所, 北京 100050;中国医学科学院协和医学院神经科学中心药物研究所, 北京 100050;湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 补益类药物根据其功效和中药适应症的不同可以分为补气药、补阴药、补血药和补阳药四类。本文以补益类中药的抗衰老作用为切入点，对补益类中药起抗衰老作用的相关主要有效成分进行总结，发现补益类中药的抗衰老有效成分主要是多糖类和皂苷类。目前已有部分多糖与皂苷在临床中使用效果明显，加之补益类中药具有资源丰富、品种繁多、成本低廉、毒副作用小等特点，因此相关补益类中药多糖成分与皂苷类成分产品值得进一步开发；可利用我国独特的中药资源优势，全面推进我国中药的产业化、现代化进程。 |
| 关键词: 抗衰老 补益类中药 补气药 补阴药 补血药 补阳药 活性成分 多糖 皂苷 |
| DOI：10.3969/j.issn.1674-070X.2016.04.020 |
| 投稿时间：2015-11-25 |
| 基金项目:国家自然科学基金项目（81274122、81373997、81273629、81473570）；国家“重大新药创制”科技重大专项（2012ZX09301002-004、2012ZX09103101-006）；教育部长江学者和创新团队发展计划（PCSIRT）（IRT1007）；教育部博士点基金重点项目（20121106130001）；北京市自然科学基金（7131013、7142115）；新药作用机制研究与药效评价北京市重点实验室资助项目（BZ0150）。 |
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| Reaearch Progress of Anti-Aging Active Ingredients of Tonic Chinese Medicine |
| LIU Shasha,AI Qidi,CHEN Naihong |
| (Central Hospital of Xiangtan, Xiangtan, Hunan 411100, China;Institute of Neuroscience Drug Center, Peking Union Medical College Hospital, China Academy of Chinese Medicine Sciences, Beijing 100050, China;Institute of Neuroscience Drug Center, Peking Union Medical College Hospital, China Academy of Chinese Medicine Sciences, Beijing 100050, China;Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Aging is the physiological changes caused by the aging of the tissues and organs, and it is the comprehensive performance of various functional decline of the organism. There are kinds of theories about aging, but the exact mechanism is still unknown. Tonic Chinese medicine, also known as the tonic Xu or Yang Chinese medicine, refers to complement of Yin and Yang deficiency of vital energy, improve heart function, enhanced physique, improve the ability to resist disease, eliminate the deficiency syndrome. Modern pharmacology study shows that it can strengthen the body's immune function, improve the body's adaptability, promote metabolism, nourish Yin and strong, and so on. Tonic Chinese medicine according to its efficacy and indications of different Chinese traditional medicine can be divided into nourishing Qi, Yin, blood and Yang tonic medicines taking four classes. Taking the anti-aging effect of tonic Chinese medicine as the breakthrough point, to summarize the main effective components of tonic Chinese medicine which have anti-aging effects, eventually found relatively the anti-aging effective components of tonic Chinese medicine is mainly of polysaccharide and saponins classes. Now there are some kinds of polysaccharide and saponins which have obvious effects in clinical use, and tonic Chinese medicine has rich resources, wide variety, low cost, low toxicity, etc, so the related ingredients like saponin and polysaccharide components of tonic Chinese medicine products are worthy of further development, take advantage of our unique traditional Chinese medicine resources, promoting the industrialization and modernization of Chinese medicine in our country. |
| Key words: anti-aging tonic Chinese medicine Qi-tonyfing medicine Yin-reinforcing medicine noridhing blood medicine Yang-reinforcing medicine active ingredients polysaccharide saponin |
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