| 引用本文: |
刘德果,李姿蓉,刘凯,陈杏元,方颖,范虹桥,胡金辉.乳腺癌(乳岩)古今文献用药规律数据挖掘[J].湖南中医药大学学报,2016,36(4):70-73[点击复制] |
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| 乳腺癌(乳岩)古今文献用药规律数据挖掘 |
| 刘德果,李姿蓉,刘凯,陈杏元,方颖,范虹桥,胡金辉 |
| (湖南中医药大学, 湖南 长沙 410208;湖南省中医药研究院附属医院, 湖南 长沙 410006;湖南中医药大学第一附属医院, 湖南 长沙 410007) |
| 摘要: |
| 目的 为全面系统地了解古今中医文献中乳腺癌（乳岩）的用药规律，总结有效治疗措施指导临床实践。方法 将相关中医文献经过数据整理后建立乳腺癌文献信息标准数据库集，并在数据整理的基础上采用Clementine 12.0进行用药关联规则分析，得出古今中医文献中关于乳腺癌的用药规律，并运用SPSS 19.0进行文献中所用药物的使用频数/频率进行聚类分析。结果 治疗乳腺癌出现频次排名前五的药物类别由多到少依次为理气药 > 活血药 > 补阳药 > 滋阴药 > 化痰药。理气药常与活血药、补阳药、滋阴药、化痰药合用。结论 乳腺癌治疗以理气化瘀药为主，联合应用化痰药、补阳药、滋阴药的用药规律切合临床实际，值得推广应用。 |
| 关键词: 乳腺癌 乳岩 补肾活血汤 关联规则 聚类分析 数据挖掘 |
| DOI：10.3969/j.issn.1674-070X.2016.04.019 |
| 投稿时间：2015-10-10 |
| 基金项目: |
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| Data Mining for Medication Rules of Breast Cancer (Mammary Cancer) in Ancient and Modern Literatures |
| LIU Deguo,LI Zirong,LIU Kai,CHEN Xingyuan,FANG Ying,FAN Hongqiao,HU Jinhui |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Academy of Chinese Medicine, Changsha, Hunan 410006, China;The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To comprehensively understand the medication rules of breast cancer (mammary cancer) in ancient and modern literatures. The clinical practice can be guided by summarized effective treatment measures. Methods The standard database of breast cancer information was built by collecting the related Chinese medicine literatures woth data integration. On the basis of the datacollecting, the association rules were annalyzed by using Clementine 12.0, and the medication rules of breast cancer were obtained. The using frequency of medicine were made clustering analysis by SPSS 19.0. Results The former five frequency of medicine was Qi-regulating drug > circulating drug > Yang-noting drug > norishing Yin drug > expectorant druguse for literature of the drugs used in treatment of breast cancer. Conclusion Qi-regulating and removing blood stasis class drug treat breast cancer for the medicine primarily, combining with expectorant drug, Yang-tonifying drug and norishing Yin drug. The medication rules conform to the clinical practice, and are worthy of popularization and application. |
| Key words: breast cancer mammary cancer norishing kidney and circulating blood decoction literature research association rules clustering analysis data mining |
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