| 引用本文: |
何群,姜宇,陈本超,陈光宇,郭锦明,谢名君.秦皮甲素两种给药途径在大鼠体内药代动力学研究[J].湖南中医药大学学报,2016,36(1):37-40[点击复制] |
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| 秦皮甲素两种给药途径在大鼠体内药代动力学研究 |
| 何群,姜宇,陈本超,陈光宇,郭锦明,谢名君 |
| (湖南中医药大学药学院, 湖南 长沙 410208;湖南省教育厅药学"十二五"重点学科, 湖南 长沙 410208) |
| 摘要: |
| 目的 研究秦皮甲素两种给药途径在大鼠体内的药代动力学。方法 秦皮甲素经大鼠灌胃（ig）和腹腔注射（ip）给药（100 mg/kg）后，采集不同时间点的大鼠血样，采用HPLC测定秦皮甲素在大鼠血浆中的浓度并计算其药代动力学参数。结果 秦皮甲素灌胃给药和腹腔注射给药两种途径的药动学均符合一级吸收一室开放模型，其关键药物动力学参数分别为AUC0→∞=（3.76±0.44） mg·h/L，（149.64±20.71） mg·h/L；Ke=（0.83±0.22）/h，（1.38±0.13）/h；Cmax=（2.63±0.60） mg/L，（164.37±16.94） mg/L；Tmax=（0.17±0.00） h，（0.17±0.00） h；T1/2（ke）=（0.88±0.21） h，（0.51±0.05） h；MRT=（1.69±0.31） h，（0.99±0.06） h。结论 秦皮甲素两种给药途径的主要药动学参数有显著性差异，腹腔注射给药代谢速度较高，可以更加有效地降低血尿酸。 |
| 关键词: 秦皮甲素 药物动力学 给药途径 HPLC |
| DOI：10.3969/j.issn.1674-070X.2016.01.008 |
| 投稿时间：2015-05-08 |
| 基金项目:湖南省教育厅计划课题（60010499）。 |
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| Pharmacokinetic Study of Aesculin in Rats of Two Administration Routine in Vivo |
| HE Qun,JIANG Yu,CHEN Benchao,CHEN Guangyu,GUO Jinming,XIE Mingjun |
| (School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Pharmaceutical "Twelfth Five-Year Plan" Key Disciplines of Department of Education of Hunan Province, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To study the pharmacokinetics of aesculin in rats of two administration routine in vivo. Methods The rats were given aesculin by intragastric administration (ip) and intraperitoneal injection (ig) with a dosage of 100 mg/kg. The plasma at different time points was collected. The concentration of aesculin in rats' plasma was determined by HPLC and its pharmacokinetic parameters were calculated. Results The pharmacokinetics of aesculin by ig and ip routine met first-order and mono-compartment model, the critical parameters shown as below, respectively: AUC0→∞=(3.76±0.44) mg·h/L, (149.64±20.71) mg·h/L; Ke=(0.83±0.22)/h, (1.38±0.13)/h; Cmax=(2.63±0.60) mg/L, (164.37±16.94) mg/L; Tmax=(0.17±0.00) h, (0.17±0.00) h; T1/2(ke)=(0.88±0.21) h,(0.51±0.05) h; MRT=(1.69±0.31) h, (0.99±0.06) h. Conclusion The pharmacokinetic parameters of aesculin by two routines showed significant difference, the ig route was with higher metabolic rate and can reduce blood uric acid effectively. |
| Key words: aesculin pharmacokinetics administration routine HPLC |
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