| 引用本文: |
刘瑞连； 严建业； 李顺祥； 陈胜璜； 罗堃；.正交试验法优选冰荷洗剂醇提工艺[J].湖南中医药大学学报,2012,32(9):33-36[点击复制] |
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| 正交试验法优选冰荷洗剂醇提工艺 |
| 刘瑞连；严建业；李顺祥；陈胜璜；罗堃； |
| (湖南中医药大学药学院 中药现代化教育厅重点实验室; 湘潭市中
心医院) |
| 摘要: |
| 目的研究冰荷洗剂最佳醇提工艺条件。方法采用正交试验,以苦参
中的主要有效成分苦参碱和氧化苦参碱的浸出量及浸膏得率为考察指标,用
L9(34)正交表安排实验,优化提取条件。结果最佳提取工艺为药材用60%乙醇
回流提取3次,溶媒加量分别为8、6、6倍,提取时间分别为2、1.5、1.5 h。结
论本实验为冰荷洗剂醇提工艺的确定提供了可靠的实验依据. |
| 关键词: 冰荷洗剂 提取工艺 正交试验 苦参碱 氧化苦参碱 高效液相色谱法 苦参 茵陈 冰片 |
| DOI： |
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| 基金项目:湖南省中医药科研计划项目(2010095);国家中医药管理局“中药药
剂学”重点学科;湖南省高校“中药新药创制与资源综合持续利用”科技创新
团队资助(湘教通[2010]212号) |
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| optimization of the ectraction technology of Binghe Lotion using theanol by orthogonal experiments |
| LIU Rui-lian1,2,YAN Jian-ye1,LI Shun-xiang1,CHEN Sheng-
huang1,LUO Kun1 |
| ((1.Key Lab of Chinese Medicine
Modernization,Pharmaceutical college,TCM University of
Hunan,Changsha Hunan 410208,China;2.Xiangtan Central
Hospital,Xiangtan,Hunan 411100,China)) |
| Abstract: |
| (Abstract〕 Objective To optimize the extraction technology
of Binghe Lotion using ethanol.
Methods The extraction technology of Binghe Lotion was optimized
with orthogonal experiment of L9
(34), taking the contents of matrine and oxymatrine which
were the main active ingredients in
Sophora flavescens and the extract yields as indexes.
Results The best extraction conditions of
Binghe Lotion using 60% ethanol as solvent were as follows: adding
8 , 6，6 times solvent into herbs,
then reflux extracting 3 times，and 2.0，1.5，1.5 h for
each time respectively. Conclusion The
study may provide reliable experiment data for the Binghe Lotion
extraction technology with ethanol. |
| Key words: Binghe Lotion extraction technology orthogonal
experiment matrine oxymatrine HPLC sophora flavescens Artemisia capillaries Thumb horned |
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