| 引用本文: |
吴大力； 谭涵宇； 彭清华；.蛴螬提取物对大鼠光损伤视网膜变性NF-κB表达及核转位的影响[J].湖南中医药大学学报,2012,32(5):35-38[点击复制] |
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| 蛴螬提取物对大鼠光损伤视网膜变性NF-κB表达及核转位的影响 |
| 吴大力；谭涵宇；彭清华； |
| (湖南中医药大学第一附属医院眼科学重点学科; 广西中医学院第一附属医院) |
| 摘要: |
| 目的探讨蛴螬提取物对大鼠光损伤视网膜变性核因子κB(NF-κB)表达的影响。方法将48只大鼠随机分成6组,分别为空白组、模型组、驻景丸组、蛴螬低、中、高剂量组,每组8只动物,16只眼。除空白组外,其余5组均建立光损伤视网膜变性模型,分组给药3周后取材做NF-κB免疫组化检测,计算机系统图像分析结果并进行统计分析。结果与模型组比较,蛴螬中、高剂量组的NF-κB积分光密度和核转位数增加,差异具有统计学意义(P<0.05)。结论蛴螬通过增加NF-κB信号通路的活化,抑制细胞凋亡死亡受体信号通路来发挥保护视网膜作用。 |
| 关键词: 光损伤 核因子κB 核转位 大鼠 |
| DOI： |
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| 基金项目:湖南省教育厅科研基金资助项目(09C729);湖南省卫生厅中医药科研基金资助项目(2010012);国家中医药管理局中医眼科学重点学科建设项目;湖南省中医五官科学重点学科建设项目 |
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| Effects of grub extracts on the expression of NF-κB and its nuclear translocation in rats' retinal degeneration by light damage |
| WU Da-li1,2,TAN Han-yu1,PENG Qing-hua1 |
| (1.Key discipline of Ophthalmology,First Affiliated Hosipital,TCM Universtiy of Hunan; 2.TCM College of Guangxi,Nanning,Guangxi) |
| Abstract: |
| Effects of grub extracts on the expression of NF-κB and its nuclear translocation in rats' retinal degeneration by light damage randomly divided into 6 groups as follows:blank group, model group, Zhujing pill group and grub extracts low, middle, high dosage group，8 rabbits with 16 eyes in each group. Except for the blank group, the others were made retinal degeneration model by light damage. After treated for 3 weeks, all rabbits were taken specimen to check NF一κB expression levels by immnohistochemistry. Results were analyzed by computer image system. Results Compared with the model group，optical density of NF一κB and the numbers of nuclear translocation in middle and high dosage grub group were increased significantly(P<0.05). Conclusion Grub can inhibit apotosis receptor signal pathway to protect retina by activating NF-KB signal pathway. |
| Key words: grub extracts light damage nuclear factor一 kappa t5 nuclear translocation rat |
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