| 引用本文: |
何群； 郭畅； 吕毅； 张湘晖； 陈光宇； 王适； 罗怀浩；.目安眼用凝胶剂卡波姆基质组方配比研究[J].湖南中医药大学学报,2012,32(3):31-33[点击复制] |
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| 目安眼用凝胶剂卡波姆基质组方配比研究 |
| 何群；郭畅；吕毅；张湘晖；陈光宇；王适；罗怀浩； |
| (湖南中医药大学药学院中药现代化实验室; 湖南中医药大学第一中医临床学院; 湖南中医药大学第二附属医院) |
| 摘要: |
| 目的筛选目安眼用凝胶剂成型最适合的基质组方,确定其最佳配比,为进一步研究奠定基础。方法以均匀性、成型性、涂展性、稠度等为评价指标,采用正交试验及等级一致性检验法,对卡波姆凝胶基质的配比进行研究。结果目安眼用凝胶卡波姆基质最佳配比为卡波姆0.8 g、甘油3.0 g和氢氧化钠0.4 g。结论确定了目安眼用凝胶卡波姆基质组方最佳配比,按该配方制备目安眼用凝胶剂,成型性最优。 |
| 关键词: 目安眼用凝胶剂 基质筛选 成型性 正交试验 等级一致性检验法 |
| DOI： |
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| 基金项目:湖南省科技厅资助项目(2008FJ3068);湖南省自然科学基金资助项目(11JJ3107) |
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| Research of proportioning carbomer matrixin Muan ophthalmic gel |
| HE Qun,GUO Chang,LU Yi,ZHANG Xiang-hui,CHEN Guang-yu,WANG Shi, LUO Huai-hao |
| (Laboratory of Chinese Medicine Modernization, TCM university of Hunan, Changsha Hunan
410208 China) |
| Abstract: |
| To select the best matrix prescription for Muan oph
thalmic gel moldability, determine the optimal proportioning and lay the foundation for the further
research. MethodsThe experimental study was determined with the evaluation indexes of the u
niformity, moldability, extensity and consistence, and the orthogonal design test methods and Hi
erarchical consistency test method. Results The best proportioning of Muan oph
thalmic gel carbomer matrix is that carbomer 0.6 g, glycerol 2.0 g, sodium hydroxide 0.2 g.
ConclusionThe best proportioning of Muan ophthalmic gel carbomer matrix have been ensured.
Preparation Muan ophthalmic gel in accor dance with this matrix proportioning, its moldability is
the best. |
| Key words: Muan ophthalmic gel matrix selecting moldability orthogonal design grading
consistency test |
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