| 引用本文: |
曹健;吴生兵;周美启;高纺;杨影;.电针对大鼠脑出血后脑血肿的影响[J].湖南中医药大学学报,2012,32(1):67-69+78[点击复制] |
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| 电针对大鼠脑出血后脑血肿的影响 |
| 曹健;吴生兵;周美启;高纺;杨影; |
| (安徽中医学院科技处; 安徽中医学院科研实验中心; 安徽中医学院中医临床学院) |
| 摘要: |
| 目的观察早期电针治疗对大鼠脑出血(intracerebral hemorrhage,ICH)后脑血肿的影响。方法从60只Wistar大鼠中随机选择10只作为假手术对照组,其余50只用于大鼠ICH模型的复制,然后根据模型成功的评判标准随机选取模型复制成功大鼠30只,再分为模型组、非经非穴组和电针组,每组各10只。电针组选取"人中"、"风府",非经非穴组选取大鼠臀部非经非穴点。电针每次20 min,每隔24 h 1次,连续3 d。假手术对照组、模型组均不予电针。结果模型组、非经非穴组、电针组大鼠均可见大小不等的出血点及血肿;镜下观察可见模型组、非经非穴组、电针组大鼠大脑注射区域均可见组织内有不同程度的血肿,周围脑组织水肿、神经细胞肿胀、细胞核碎裂溶解或消失、组织内可见红细胞,有不同程度的炎性细胞浸润等;与非经非穴组、模型组比较,电针组血肿直径明显减小,差异有统计学意义(P<0.05)。结论针刺早期介入,可减小脑血肿的直径,能有效控制ICH后脑血肿的发生、发展,对保护脑组织具有一定的意义。 |
| 关键词: 电针 脑出血 脑血肿 大鼠 |
| DOI： |
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| 基金项目:安徽中医学院自然科学基金资助项目(2010zr017B) |
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| Effects of electroacupuncture treatment on cerebralhematoma after intracerebral hemorrhagein rats |
| CAO Jian1,WU Sheng-bing2,ZHOU Mei-qi3,GAO Fang3,YANG Ying3 |
| (1.Department of Science and Technology,Anhui College of Traditional Chinese Medicine,Hefei,Anhui 230038,China; 2.Experimental Research Center,Anhui College of Traditional Chinese Medicine,Hefei,Anhui 230038,China; 3.Department of Traditional Chinese Medicine,Anhui College of Traditional Chinese Medicine,Anhui,Hefei 230038,China) |
| Abstract: |
| (Abstract〕 Objective To investigate the therapeutic effect of electroacupuncture treatment on
the early stage of cerebral hematoma formation following after intracerebral hemorrhage (ICH) in
rats. Methods Ten animals were randomly selected as sham operation group(SOG) from 60 Wistar
rats and the remaining rats were used to prepare the model of cerebral hematoma after ICH. Then
30 modeled rats were randomly divided into 3 groups, i.e. model group(MG), extra-meridians
acupoints group(EMG) and electro-acupoint group(EAG), 10 rats per group. Acupoints Renzhong
(DU26) and Fenngfu(DU26) were used in EAG and the extra-point in hips of rats in EMG; elctro-
puncturing 20 mins, once 24 hours, and lasting 3 days; and the electro-puncturing were used not
in SOG and MG. Results Except for SOG, the various size of bleeding spots and hematomas were
within cerebral issue; under the microscopic observation, the different degrees of cerebral edema
around the hematoma, swelling nerve cells, nucleus fragmentation dissolve or disappear, red
blood cells visible within the organization were seen in rat brain tissue within the injection area
and there existed different degrees of inflammatory cell infiltration; compared with EMG and
MG, hematoma diameter were significantly reduced in EAG(P<0.05). Conclusion Early acupuncture
intervention can significantly reduce the size of hematoma and effectively control the occurrence
and development of cerebral hematoma following ICH. |
| Key words: electroacupuncture intracerehral hemorrhage cerebral hematoma rats |
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