| 引用本文: |
陈孟交;王桂蒙;肖四旺;陆小龙;尤冬春;.丹紫康膝冲剂对兔膝骨性关节炎软骨含水率及羟脯氨酸影响的研究[J].湖南中医药大学学报,2012,32(1):20-22[点击复制] |
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| 丹紫康膝冲剂对兔膝骨性关节炎软骨含水率及羟脯氨酸影响的研究 |
| 陈孟交;王桂蒙;肖四旺;陆小龙;尤冬春; |
| (湖南中医药大学第二附属医院) |
| 摘要: |
| 目的探讨丹紫康膝冲剂兔膝关节骨性关节炎软骨含水率及羟脯氨酸的影响。方法将兔随机分成6组,除正常组外,丹紫康膝冲剂高剂量组、中剂量组、低剂量组(简称丹紫高、中、低剂量组)、壮骨关节丸组(简称壮骨组)、模型组共5组分别在兔左膝关节1、4、7 d注射0.5 mL 4%木瓜蛋白酶造模及药物干预后,光镜下观察关节软骨并检测关节软骨含水率和羟脯氨酸含量。结果模型组发生明显膝关节软骨退行性改变。丹紫高、中、低剂量组与模型组比软骨含水率差异有统计学意义(P<0.05),丹紫高、中、低剂量组与模型组软骨羟脯氨酸含量比较差异有统计学意义(P<0.05);丹紫高、中剂量组软骨含水率比较两组间差异无统计学意义(P>0.05),高、中剂量组软骨含水率与丹紫低剂量组比较差异有统计学意义(P<0.05);丹紫高、中剂量组软骨羟脯氨酸含量比较两组间差异无统计学意义(P>0.05),高、中剂量组软骨羟脯氨酸含量与丹紫低剂量组比较差异有统计学意义(P<0.05)。结论丹紫康膝冲剂能改善兔膝关节骨性关节炎软骨中含水率和羟脯氨酸含量,且高、中剂量效果为佳。 |
| 关键词: 丹紫康膝冲剂
膝骨性关节炎
软骨
轻月甫氨酸
兔
紫河车
丹参 |
| DOI： |
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| 基金项目:湖南省自然科学基金资助项目(09JJ6055) |
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| Effects of Danzi Kangxi granule on cartilage waterand hydroxyproline of knee osteoarthritis in rabbits |
| CHEN Meng一iao, WANG Gui-meng, XIAO Si-wang, LU Xiao-long, YOU Dong-chun |
| (Second Affiliated Hospital, TCM University of Hunan) |
| Abstract: |
| (Abstract〕 Obj ective To investigate the effects of Danzi I}angxi granule (DING) on
the content of water and hydroxyproline in cartilage of rabbits with knee osteoarthritis. Methods
Rabbits were randomly divided into 6 groups, i.e. DING high dose group(HDG), medium dose group
(MDG), low dose group (LDG), modeling control group (MCG) and Bone -Strengthening Joint
Pills group (BSJPG). Except the control group, all the rabbits were treated with 0.5 mL 4% papain
injected into the left knee joints in the 1st, 4th and 7th days in one week. Then, the cartilage
water and hydroxyproline were determined. Results Obvious degenerative pathological changes were
found in the in MCG. Compared with MCG, the content of cartilage water and hydroxyproline
were markedly lower in HDG, MDG and LDG statistically(P<0.05); the cartilage water content in in
HDG and MDG were lower than that in LDG (P<0.051: the differences of hvdroxvnroline between HDG and MDG was not significant(P<0.05),but data of there two groups have significant differences comparing with LDG (P<0.05). Conclusion Danzi Kangxi granule can
levels of cartilage water and hydroxyproline in knee osteoarthritis, in which
improve the
the high
and medium dosage
are much bearer in rabbits. |
| Key words: Key words Danzi Kangxi granule knee osteoarthritis cartilage hydroxyproline rab-
bits dried human placenta salvia |
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