| 引用本文: |
俞悦，易健，蔡光先，刘柏炎.Caveolin-1敲除对C57BL/6小鼠繁殖性能及子代离乳前体质量的影响[J].湖南中医药大学学报,2011,31(11):7-8[点击复制] |
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| Caveolin-1敲除对C57BL/6小鼠繁殖性能及子代离乳前体质量的影响 |
| 俞悦，易健，蔡光先，刘柏炎 |
| (湖南中医药大学省部共建教育部重点中医内科实验室，湖南长沙410007) |
| 摘要: |
| 目的探讨小窝蛋白Caveolin-1敲除对C57BL/6小鼠离乳前繁殖性能及体质量的影响〔方法分别对Caveolin-1基因敲除小鼠和同源C57小鼠进行体质量、初产日龄、胎次间隔时间、平均产仔数及离乳存活率的观察及分析、结果C57BL/6小鼠鼠仔平均体质量均高于Caveolin-1基因敲除鼠，在1,7,14 d时两者比较差异无统计学意义(P>0.05);21 d时，两者差异具有统计学意义(P<0.05 );两组初产日龄、胎次间隔时间及平均产仔数差异无统计学意义(P>0.05)，但C57BL/6小鼠离乳存活率明显高于基因敲除鼠，两者差异具有统计学意义(P<0.05)、结论Caveolin-1敲除小鼠的体质量下降、繁殖性能下降、 |
| 关键词: 小窝蛋白 基因敲除小鼠 体质量 繁殖性能 |
| DOI： |
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| 基金项目:国家自然科学基金资助项日(30873355);教育部博卜点专项科研基金资助项日(20060541007);湖南省教育部重点资助项日(209087);湖南省教育厅重点资助项日(08A049) |
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| Effect of Caveolin-1 knockout on weight and reproductive performance before weaning in C57BL/6 mice |
| YU Yue, YI Jian, CAI Guang-xian, LIU Bai-yan |
| (key lab of Iinternal Medicine Constructed by Changsha, Hunan Ministry -Province, TCM University of Hunan 410007, China) |
| Abstract: |
| Objective evaluate the effects of Caveolin-1 knockout on weight and reproductive performance before weaning in C57BL/6 mice. Methods The growth curves, primiparous age, parity time interval, the average litter sizes and weaning survival were observed and analyzed respectively in caveolin一1 knockout mice and C57 mice homologous. Results The average body weight of C57BL/6 newborn mice were higher than that of Caveolin一1 knockout mice in 1st, 7th and 14th days, but there were no significant differences (P>0.05); in 21st day, the difference was significant (P<0.05); the primiparous age, parity, litter size and the average interval between the two was no significant difference (P>0.05), but the survival rate of C57BL/6 mice was significantly higher than that of knockout mice(P<0.05). Conclusion Caveolin-1 knockout can slow the growth and decrease the reproductive ability of C57BL/6 mice. |
| Key words: Caveolin-1 kncok-out mice growth curve body weight reproductive performance |
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