| 引用本文: |
卢敏 谭旭仪 谢心军 龚志贤 左亚杰 严
可 刘鑫.伤速康贴膏对兔膝骨性关节炎模型关节液中
IL-1, IL-6及TNF-。水平的影响[J].湖南中医药大学学报,2011,31(7):18-21[点击复制] |
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| 伤速康贴膏对兔膝骨性关节炎模型关节液中
IL-1, IL-6及TNF-。水平的影响 |
| 卢敏谭旭仪谢心军龚志贤左亚杰严
可刘鑫 |
| ((1湖南中医药大学第一附属医院，湖南长沙410007;2湖南中医药大学2004级一七年制木硕连读班，湖南长沙410208
3.湖南中医药大学2009级硕士研究生班，湖南长沙410208)) |
| 摘要: |
| 目的 探讨伤速康贴膏对兔膝骨性关节炎模型关节液中IL-1, IL-6及TNF-。水平的影响〔方法选用
口木大耳白兔30只随机分成模型组(A组)、伤速康贴膏组(B组)及骨通贴膏组(C组),B,C组采用改良Hulth造模
法5周后成功复制出兔膝骨性关节炎模型,A组不做任何治疗，B,C组分别予伤速康贴膏和骨通贴膏右膝关节外敷
4周，并于用药后第2周、4周2个时相点行右膝关节DR摄影并测定关节液中IL-1 ,IL-6及TNF-a含量〔结果2
个时相点右膝关节DR摄影示B,C组关节退行性改变较A组轻〔3组关节液中均可检测到IL-1 ,IL-6及TNF-a,B,
C组在2个时相点含量均低于A组，差异有显著统计学意义(P<0.01),B,C组在2个时相点均无统计学差异(乃
0.05 )、结论伤速康贴膏可能通过降低关节液IL-1,IL-6及TNF-。的含量，对膝骨性关节炎具有防治作用、 |
| 关键词: 膝骨性关节炎 伤速康贴膏 骨通贴膏 IL-1 IL-6 TNF-a 兔 大黄 桅子 银花 |
| DOI： |
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| 基金项目:湖南省自然科学基金资助项目(09jj6050) |
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| Effectsandof ShangsukangTNR-a levelsemplastrum onin synovia fluidIL-1, IL-6of kneeosteoarthritisin rabbits |
| LU Min, TAN Xu-yi, XIE Xin一un, GONG Zhi-xian, ZUO Ya一ie, YAN Ke, LIU Xin |
| (First Affiliated Hospital, TCM University of Hunan, Changsha, Hunan, 410007, China)) |
| Abstract: |
| [Abstract] Objective To
the effects of Shangsukang emplastrum on IL-1,
TNR-cx levels in synovia fluid of knee osteoarthritis in rabbits. Methods 30 Japanese white rab-
bits were randomly divided into model group (Ga), Shangsukang group (Gb) and Gutong group (Gc).
The rabbits in Gb and Gc were established the model by ameliorated Hulth's method and
the models were reformed 5 weeks later, and then, they were treated by Shangsukang emplastrum
and Gutong emplastrum in 4 weeks, and in Ga they were not be treated. At the 2nd and the
4th week, the radiography examination was taken and the contents of IL一1, IL-6 and TNF-cx in
each group were determined respectively on the right knees. Results At both two time points,
an(l﹄()s-
the degeneration changes in knee in Gb and Gc were lighter than Ga,
TNF-cx in Gb and Gc were lower than Ga (P>0.01), but the difference
all the IL一1,IL-6
between Gb andG〔:
no sgnificant (P >0.05). Conclusion Shangsukang emplastrum can
prevent and
cure knee osteoarthritis, which may be acted
fluid.
()n
lowering the content of IL一1,IL-6 and TNF-cx in synovia |
| Key words: (Key words〕 knee osteoarthritis Shangsukang emplastrum Gutong emplastrum IL-1 IL-
6 TNF-cx rabbits Rhubarb Gardenia Honeysuckle flower |
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