| 引用本文: |
徐德宏 陈仁忠 池宇朋 蔡丽君 文宁 肖玉成 王贤纯 曾雄智 梁宋平.敬钊毒素一V对吗啡成瘾小鼠戒断症状的影响[J].湖南中医药大学学报,2011,31(7):11-13[点击复制] |
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| 敬钊毒素一V对吗啡成瘾小鼠戒断症状的影响 |
| 徐德宏陈仁忠池宇朋蔡丽君文宁肖玉成王贤纯曾雄智梁宋平 |
| ((1.湖南师范大学蛋白质化学与发育生物学教育部重点实验室，湖南长沙410081
2湖南中医药大学，湖南长沙410208)) |
| 摘要: |
| 目的观察Jingzhaotoxin-V敬钊毒素一V(JZTX-V)对纳洛酮催促戒断症状的治疗作用。方法建立吗啡
成瘾小鼠模型，分别测定4组不同剂量S , SO , S00 ,1000 },g}kg JZTX-V对小鼠戒断后跳跃次数的影响〔结果JZTX-
V在戒断后的15min内能减少小鼠的跳跃次数，而且5,50和500 },g/kg JZTX-V对跳跃次数的抑制具有统计学意
义((P<0.05 ,P<0.01)〔结论JZTX-V在S-S00 }e.g}kg范围内能显著抑制小鼠戒断后的跳跃次数，有可能成为一种戒毒
先导分子、 |
| 关键词: 敬钊毒素一V 吗啡依赖 戒断症状 纳洛酮 小鼠 |
| DOI： |
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| 基金项目:国家973项日(2009CB526510,2010CB529800),863项日(2006AA02Z141),湖南省自然科学基金资助项日(07JJ3072);教育部新
川_纪优秀人才支持计划(NCET-07-0279)资助:湖南省教育厅重点项日(OTA035 ) |
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| Effects of inJZTX-Vmorphineon withdrawl symptomsdependent mice |
| XU De-bong, CHEN Ren-zhong, CHI Yu-peng, CAI Li一un, WANG Xian-chun |
| ((I}ey Lalx>ratory of Protein Chemistry and Developmental Biology of Ministry of Education, Hunan
Normal University, Changsha, Hunan, 410081, China) |
| Abstract: |
| (Abstract〕 Objective To observe the treatment effects of Jingzhaotoxin-V(JZTX-V) on with-
drawl symptoms aroused by Naloxone precipitation. Methods The mice models with morphine ad-
diction were divided in 5, 50, 500 and 1000 N.,g/kg JZTX-V groups and each dose affected on
the jumping times of mice after withdrawl. Results The JZTX -V二、luced the jumping times
of mice during the 15 minutes after withdrawl, and the doses 5, 50 and 500 N.,g/kg JZTX-V
were significant[()inhibit the jumping times (P<0.05 and P<0.01). Conclusion When the doses
between 5 and 500 N.,g/kg, JZTX-V can significantly二、luce jumping times of mice after with-
drawl. which may be a leading molecule[()be betting rid of drugs. |
| Key words: (I}ey Lalx>ratory of Protein Chemistry and Developmental Biology of Ministry of Education, Hunan
Normal University, Changsha, Hunan, 410081, China) |
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