| 引用本文: |
曾普华； 蒋益兰； 蔡美； 潘敏求；.鸦胆子油乳经胸腔热灌注治疗恶性胸腔积液的临床研究[J].湖南中医药大学学报,2011,31(5):51-53[点击复制] |
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| 鸦胆子油乳经胸腔热灌注治疗恶性胸腔积液的临床研究 |
| 曾普华；蒋益兰；蔡美；潘敏求； |
| (国家中医药管理局重点学科湖南省中医药研究院附属医院; 湖南中医药大学附属中西结合医院肿瘤科) |
| 摘要: |
| 目的初步评价鸦胆子油乳经胸腔热灌注治疗恶性胸腔积液的临床疗效。方法 30例恶性胸腔积液患者经胸腔内置管引流排尽胸水,反复3次往腔内灌注45℃生理盐水800～1 000 mL,每次保留20 min后充分排尽,最后将45℃生理盐水100 mL+地塞米松15 mg+鸦胆子油乳60 mL注入胸腔,与胸水引流后经常温生理盐水100 mL+地塞米松15 mg+顺铂50 mg/m2胸腔灌注化疗的30例进行对照。每周1次,共治疗2次。结果治疗组总有效率为86.7%,对照组总有效率为63.3%,两组近期疗效差异有统计学意义(P<0.05);两组生活质量(Karnofsky标准评分)治疗后均较治疗前明显提高,差异有统计学意义(P<0.01);其中治疗组提高幅度大于对照组,差异有统计学意义(P<0.01);治疗组较对照组毒副反应发生率明显减少(P<0.05)。结论鸦胆子油乳经胸腔热灌注治疗恶性胸腔积液有效率高,能改善患者生存质量,毒副反应轻。 更多还原 |
| 关键词: 恶性胸腔积液 鸦胆子油乳 热灌注 |
| DOI： |
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| 基金项目:国家中医药管理局重点学科(中医肿瘤病学)人才培养基金资助(2010) |
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| Clinical study of kosum grease emulsionvia perfusion for malignant pleural effusion |
| ZENG Pu-hua,JIANG Yi-lan,CAI Mei,PAN Min-qiu |
| (Affiliated Integrated Chinese and Western Hospital,TCM University of Hunan,Changsha, Hunan 410006,China)) |
| Abstract: |
| Objective To evaluate the clinical efficacy of kosum grease emulsion via perfsion for the malignant pleural effusion. Methods 30 patients with malignant pleural effusion were drained with the chest drainage tube, then, the normal saline 800一1000 mL at 45 0C wasinstilled, after retaining 20 minutes, the saline was drained fully, repeated 3 times, and in the fi-nal time, the 45 0C saline 100 mL+Dexamethasone 15 mg+kosum grease emulsion 60 mL was in-stilled into the chest, which was compared with that 30 patients treated with pleu-ral chemotherapy, after pleural drainage, the warm saline 100 mL+dexamethasone 15 mg+cisplatin 50 mg/mz was instilled, 1 time 1 week, total twice. Results The total effective rate was 86.7% in treatment group, 63.3% in control group (P=0.030); according[()I}arnofsky standard sc<)二，the lifequality of patients in both groups was improved after treatment(all P=0.001); |
| Key words: malignant pleural effusion kosum grease emulsion infusion |
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