| 引用本文: |
李琪琳,胡元会,王欢,王强,张林淮.中医药防治心力衰竭心肌线粒体损伤的研究进展[J].湖南中医药大学学报,2021,41(11):1813-1816[点击复制] |
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| 中医药防治心力衰竭心肌线粒体损伤的研究进展 |
| 李琪琳,胡元会,王欢,王强,张林淮 |
| (中国中医科学院望京医院, 北京 100102;中国中医科学院广安门医院, 北京 100053) |
| 摘要: |
| 心肌线粒体损伤是心力衰竭病理生理机制的重要环节之一，线粒体保护途径已成为防治心力衰竭损伤的研究热点。中医药能够通过稳定线粒体膜电位、增强呼吸链复合体活性、调节钙浓度、减轻氧化应激、调控细胞凋亡、保护mtDNA等作用来减轻心力衰竭对心肌线粒体的损伤。本文就近年来中医药改善心力衰竭心肌线粒损伤研究进展作一综述，以期为中医药防治心衰提供客观的科学依据。 |
| 关键词: 中医药 心力衰竭 心肌线粒体 作用机制 |
| DOI：10.3969/j.issn.1674-070X.2021.11.029 |
| 投稿时间：2021-09-14 |
| 基金项目:北京市自然科学基金项目（7122154）。 |
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| Research Progress of Traditional Chinese Medicine in Treating Myocardial Mitochondrial Injury in Heart Failure |
| LI Qilin,HU Yuanhui,WANG Huan,WANG Qiang,ZHANG Linhuai |
| (Wang Jing Hospital of China Academy of Chinese Medical Sciences, Beijing 100102, China;Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Beijing 100053, China) |
| Abstract: |
| Myocardial mitochondrial injury is one of the important links in the pathophysiological mechanism of heart failure. Mitochondrial protection pathway has become a research hotspot in the prevention and treatment of heart failure injury. Traditional Chinese medicine can reduce the damage of heart failure to myocardial mitochondria by stabilizing mitochondrial membrane potential, enhancing the activity of respiratory chain complex, regulating calcium concentration, reducing oxidative stress, regulating cell apoptosis and protecting mtDNA. This paper reviews the research progress of traditional Chinese medicine in improving myocardial mitochondrial injury in heart failure in recent years, in order to provide objective scientific basis for traditional Chinese medicine in the prevention and treatment of heart failure. |
| Key words: traditional Chinese medicine heart failure myocardial mitochondrial mechanism of action |
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