| 引用本文: |
李志明,胡凯文,范毅南,王玥慧,罗昌国,吴非泽,张燕娜,王芬.益气化痰法对NSCLC含铂类化疗方案增效减毒的Meta分析[J].湖南中医药大学学报,2020,40(8):1004-1012[点击复制] |
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| 益气化痰法对NSCLC含铂类化疗方案增效减毒的Meta分析 |
| 李志明,胡凯文,范毅南,王玥慧,罗昌国,吴非泽,张燕娜,王芬 |
| (北京中医药大学, 北京 100029;北京中医药大学东方医院, 北京 100078;山西中医药大学, 山西 太原 030024;广东省深圳市宝安中医院, 广东 深圳 518133;北京中医药大学第三附属医院, 北京 100029) |
| 摘要: |
| 目的 评价益气化痰法对非小细胞肺癌（non-small cell lung cancer,NSCLC）含铂类化疗方案增效减毒的临床疗效。方法 计算机检索国内外中文和英文数据库，检索时间限定为建库至2019年10月31日，收集所有具有益气化痰功效的中药复方治疗NSCLC的临床随机对照试验，由两名研究者独立进行文献筛选、资料提取及质量评价后，采用Revman 5.3软件进行Meta分析。结果 最终纳入文献6篇，共525例患者。Meta分析结果显示：与对照组（单用含铂类化疗治疗）相比，治疗组（益气化痰方药联合含铂类化疗治疗）可有效稳定肺癌病灶、控制肿瘤进展、提高患者生活质量、降低肿瘤标志物表达水平、改善临床症状（咳嗽）、减轻化疗后副反应（白细胞减少、血红蛋白减少及消化道反应减少），上述各项结局指标的差异均有统计学意义（P<0.05）。结论 益气化痰法治疗NSCLC安全有效，其与含铂类化疗方案联用具有增效减毒的协同优势，可有效提高铂类方案的临床疗效，降低毒副作用，值得进一步推广应用。 |
| 关键词: 益气化痰法 非小细胞肺癌 含铂类化疗方案 增效减毒 Meta分析 |
| DOI：10.3969/j.issn.1674-070X.2020.08.018 |
| 投稿时间：2019-11-20 |
| 基金项目:国家自然科学基金项目（81573798）；北京市科委首都临床特色研究课题（Z121107001012077）。 |
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| Meta-analysis of the Efficacy Enhancing and Toxicity Reducing of Platinum Containing Chemotherapy Scheme for NSCLC by the Method of Benefiting Qi and Dissipating Phlegm |
| LI Zhiming,HU Kaiwen,FAN Yinan,WANG Yuehui,LUO Changguo,WU Feize,ZHANG Yanna,WANG Fen |
| (Beijing University of Chinese Medicine, Beijing 100029, China;Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China;Shanxi University of Chinese Medicine, Taiyuan, Shanxi 030024, China;Shenzhen Bao'an Traditional Chinese Medicine Hospital, Shenzhen, Guangdong 518133, China;The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China) |
| Abstract: |
| Objective To evaluate the clinical effects of the method of benefiting Qi and dissipating phlegm in the efficacy enhancing and toxicity reducing of platinum containing chemotherapy scheme for non-small cell lung cancer (NSCLC). Methods Chinese and English databases in China and abroad were searched by computer. The searching time was limited from database establishment to October 31, 2019. Clinical randomized controlled trials of Chinese herbal compound prescriptions with effects of benefiting Qi and dissipating phlegm on NSCLC were collected. After literature screening, data extraction and quality evaluation were performed by two researchers independently. Revman 5.3 software was used for meta-analysis. Results Totally 6 papers were included in the literature, with a total of 525 patients. Meta-analysis results showed that compared with the control group (platinum containing chemotherapy scheme alone), the treatment group (Yiqi Huatan Formula + platinum containing chemotherapy scheme) can effectively stabilize lung cancer focus, control tumor progress, improve patients' quality of life, reduce tumor markers, improve clinical symptoms (cough), and reduce side effects (leukopenia, hemoglobin reduction and gastrointestinal reaction) after chemotherapy; the differences of the above outcome indicators were statistically significant (P<0.05). Conclusion It is safe and effective to treat NSCLC with the method of benefiting Qi and dissipating phlegm. It has the synergetic advantage of efficacy enhancing and reducing toxicity with platinum containing chemotherapy scheme. It can effectively improve the clinical efficacy of the platinum plan and reduce the toxic and side effects. It is worthy of further promotion and application. |
| Key words: method of benefiting Qi and dissipating phlegm non-small cell lung cancer platinum containing chemotherapy scheme efficacy enhancing and toxicity reducing Meta-analysis |
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