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李诗卉,邓静,粟倩,梁诗瑶,伊美瑾,林丽美,孙维广.夏枯草果实石油醚提取物GC-MS分析及抗炎活性研究[J].湖南中医药大学学报,2020,40(6):689-692[点击复制] |
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| 夏枯草果实石油醚提取物GC-MS分析及抗炎活性研究 |
| 李诗卉,邓静,粟倩,梁诗瑶,伊美瑾,林丽美,孙维广 |
| (湖南中医药大学药学院, 湖南 长沙 410208;湘产大宗药材品质评价湖南省重点实验室, 湖南 长沙 410208;广州白云山星群(药业)股份有限公司, 广东 广州 510288) |
| 摘要: |
| 目的 表征夏枯草果实石油醚提取物化学成分，评价其抗炎活性。方法 采用气相色谱-质谱联用（GC-MS）对夏枯草果实的化学成分进行分析。建立RAW264.7细胞炎症模型，评价其抗炎效果。结果 共鉴定夏枯草果实石油醚提取物中19个化学成分。抗炎活性发现，夏枯草果实石油醚提取物均具有明显的抗炎效果。结论 夏枯草果实石油醚提取物成分及抗炎活性均具一定差异性。 |
| 关键词: 夏枯草果实 石油醚提取物 气相色谱-质谱联用 抗炎 |
| DOI：10.3969/j.issn.1674-070X.2020.06.009 |
| 投稿时间：2020-01-14 |
| 基金项目:“中医药现代研究”国家重点研发计划（2017YFC1701900）；长沙市科技计划项目（Kq1801046，Kq1804027）。 |
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| Analysis of Petroleum Ether Extract from Prunella Vulgaris L. Fruit by GC-MS and Its Anti-inflammatory Activity |
| LI Shihui,DENG Jing,SU Qian,LIANG Shiyao,YI Meijin,LIN Limei,SUN Weiguang |
| (School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province, Changsha, Hunan 410208, China;Guangzhou Baiyun Mountain Star Group(Pharmaceutical) Co., Ltd., Guangzhou, Guangdong 510288, China) |
| Abstract: |
| Objective To characterize the chemical constituents of petroleum ether extract from prunella vulgaris L. fruit, and to evaluate its anti-inflammatory activity. Methods GC-MS was used to detect the chemical constituents of the fruits of prunella vulgaris L. The RAW264.7 cell inflammation model was established, and its anti-inflammatory effect was evaluated. Results A total of 19 chemical compounds were identified from Prunella vulgaris L. The research on anti-inflammatory activity found that the petroleum ether extracts of Prunella vulgaris L. had significant anti-inflammatory effects. Conclusion The costituents and anti-inflammatory activities of the petroleum ether extracts of Prunella vulgaris L. have certain differences. |
| Key words: fruit of Prunella vulgaris L. petroleum ether extract GC-MS anti-inflammatory |
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