| 引用本文: |
王鸿燕,赵月娥.血脂康胶囊联合雷火灸对颈动脉粥样硬化患者血脂、血管内皮功能及相关因子蛋白的影响研究[J].湖南中医药大学学报,2020,40(4):473-477[点击复制] |
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| 血脂康胶囊联合雷火灸对颈动脉粥样硬化患者血脂、血管内皮功能及相关因子蛋白的影响研究 |
| 王鸿燕,赵月娥 |
| (海南省中医院, 海南 海口 570203) |
| 摘要: |
| 目的 观察血脂康胶囊联合雷火灸对颈动脉粥样硬化患者血脂、血管内皮功能及相关因子蛋白的影响。方法 将纳入观察的94例颈动脉粥样硬化患者随机分为观察组和对照组（各47例），对照组患者予以单纯口服阿托伐他汀钙治疗，观察组在对照组基础上加以口服血脂康联合雷火灸（灸关元、气海、足三里三穴）；每4周为1个疗程，共治疗3个疗程，观察两组患者的阿托伐他汀钙口服剂量，对比治疗前后的血脂水平、颈动脉超声检查结果和相关因子蛋白水平。结果 （1）观察组有2例患者、对照组有1例患者要求退出本研究，其余91例患者血脂控制均已达标。观察组患者阿托伐他汀钙的日均剂量为（10.5±1.3）mg/d，明显低于对照组患者的（18.3±2.5）mg/d（P<0.05）；（2）两组患者治疗后的TC、TG和LDL-C均有明显下降，而HDL-C则有明显上升，与治疗前相比差异均有统计学意义（P<0.05）；但治疗后两组上述指标比较差异无统计学意义（P>0.05）；（3）两组患者治疗后的颈动脉内膜中层厚度（CIMT）和斑块面积与治疗前相比均有明显下降（P<0.05）；且观察组CIMT和斑块面积均低于对照组（PP<0.05）；且观察组的ET-1和MMP-9均低于对照组，而NO和TIMP-1则明显高于对照组（P<0.05）。结论 血脂康胶囊联合雷火灸能控制血脂水平，缩小颈动脉硬化斑块，改善血管内皮功能，其机制可能与调整基质金属蛋白酶的平衡，促进血管内皮修复有关。 |
| 关键词: 颈动脉粥样硬化 血脂康 雷火灸 血管内皮功能 |
| DOI：10.3969/j.issn.1674-070X.2020.04.017 |
| 投稿时间：2019-12-12 |
| 基金项目:海南省自然科学基金项目（818MS158）。 |
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| Effects of Xuezhikang Capsules Combined with Thunder-Fire Moxibustion Blood Lipid, Vascular Endothelial Function and Related Factor Proteins in Patients with Carotid Atherosclerosis |
| WANG Hongyan,ZHAO Yue'e |
| (Hainan Provincial Hospital of Traditional Chinese Medicine, Haikou, Hainan 570203, China) |
| Abstract: |
| Objective To observe the effects of Xuezhikang Capsule combined with thunder-fire moxibustion blood lipid, vascular endothelial function and related factor proteins in patients with carotid atherosclerosis. Methods A total of included 94 patients with carotid atherosclerosis were randomly divided into an observation group (47 cases) and a control group (47 cases). The control group was treated with oral administration of atorvastatin calcium alone, while the observation group was treated with oral administration of Xuezhikang combined with thunder-fire moxibustion on Guanyuan (CV4), Qihai (CV6) and Zusanli (ST36) on the basis of the control group. Every 4 weeks was one treatment course, and with total 3 treatment courses. The oral dose of atorvastatin calcium of the 2 groups was counted, and the blood lipid level, carotid ultrasound results and related factor protein level before and after treatment were compared. Results (1) 2 patients in the observation group and 1 patient in the control group ask for quitting the study. The remaining 91 patients had achieved blood lipid control. The daily average dose of atorvastatin calcium in the observation group was (10.5±1.3) mg/d, which was significantly lower than (18.3±2.5) mg/d in the control group (P<0.05); (2) After treatment, TC, TG and LDL-C of the 2 groups were significantly decreased, while HDL-C was significantly increased, and there was statistically significant difference when compared with before treatment (P<0.05). However, there was no statistically significant difference between the 2 groups in the above index after treatment (P>0.05). (3) After treatment, the (carotis intima media thickness, CIMT) and plaque area of the 2 groups decreased significantly when compared with before treatment (P<0.05), and the CIMT and plaque area of the observation group were lower than that of the control group (P<0.05). (4) After treatment, ET-1 and MMP-9 of the 2 groups were significantly decreased, while NO and TIMP-1 were significantly increased. There was statistically significant difference when compared with before treatment (P<0.05). ET-1 and MMP-9 of the observation group were lower than those of the control group, while NO and TIMP-1 were significantly higher than those of the control group (P<0.05). Conclusion Xuezhikang Capsule combined with thunder-fire moxibustion can control blood lipid level, reduce carotid atherosclerotic plaque and improve vascular endothelial function. Its mechanism may be related to the regulation of matrix metalloproteinase balance and the promotion of vascular endothelial repair. |
| Key words: carotid atherosclerosis Xuezhikang Capsule thunder-fire moxibustion vascular endothelial function |
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