| 引用本文: |
黄宗文,袁勇,卢茜.中药补肾方联合恩替卡韦对乙肝患者肝纤维化、炎症反应及免疫功能的影响[J].湖南中医药大学学报,2017,37(12):1391-1395[点击复制] |
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| 中药补肾方联合恩替卡韦对乙肝患者肝纤维化、炎症反应及免疫功能的影响 |
| 黄宗文,袁勇,卢茜 |
| (海南医学院第一附属医院 海南 海口 570000;海南省干部疗养院 海南 海口 571100) |
| 摘要: |
| 目的 探讨中药补肾方联合恩替卡韦治疗对乙肝患者肝纤维化、炎症反应及免疫功能的临床观察。方法 将60例乙肝患者随机分为联合组和单药组，每组各30例，单药组给予恩替卡韦片口服治疗（0.5 mg/次，1次/日，连续治疗6个月），联合组在此基础上给予中药补肾方口服治疗（1剂/日，早晚各服1次，连续治疗6个月）。对比两组患者治疗3、6个月时的中医临床证候积分、血清中肝纤维化指标、外周血中免疫细胞含量及血清中细胞因子含量情况。结果 治疗3、6个月后，两组患者中医临床证候积分均降低，联合组降低程度高于单药组，差异有统计学意义（P<0.05）；两组患者HA、LN、PC-Ⅲ、Ⅳ-C均降低，联合组降低程度高于单药组，差异有统计学意义（P<0.05）；两组患者外周血中CD3+、CD4+、CD4+/CD8+均升高，联合组升高程度高于单药组，CD8+均降低，联合组降低程度高于单药组，差异有统计学意义（P<0.05）；两组患者血清IL-15、IL-16、TGF-β均降低，联合组降低程度高于单药组，差异有统计学意义（P<0.05）。结论 中药补肾方联合恩替卡韦治疗能有效改善乙肝患者的临床证候，能够调节免疫应答、炎症反应，以及能延缓肝纤维化，值得临床作进一步推广。 |
| 关键词: 中药补肾方 恩替卡韦 乙肝 肝纤维化 炎症反应 免疫功能 |
| DOI：10.3969/j.issn.1674-070X.2017.12.022 |
| 投稿时间：2017-09-05 |
| 基金项目:2014年海南省自然科学基金（0104777039）。 |
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| Effect of Zhongyao Bushen Decoction Combined with Entecavir on Liver Fibrosis, Inflammation and Immune Function in Hepatitis B Patients |
| HUANG Zongwen,YUAN Yong,LU Qian |
| (The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570000, China;Hainan Cadre Sanatorium, Haihou, Hainan 571100, China) |
| Abstract: |
| Objective To investigate Bushen Huoxue decoction combined with entecavir in treatment of liver fibrosis, inflammation and immune function of patients with hepatitis B. Methods 60 hepatitis B patients were randomly divided into the combined group and the single group, 30 cases in each group. The single group was given entecavir tablets (0.5 mg/time, 1 times/day, treatment for 6 months), the combined group was given Bushen Huoxue decoction (1 dose/day, once in the morning and in the evening, treatment for 6 months). on the basis of the single group. The clinical syndromes of TCM, the serum liver fibrosis index, the contents of immune cells in peripheral blood, and the content of cytokine in serum in the three or six months after treatment. Results After treatment for 3 and 6 months, the clinical symptoms of TCM decreased in both groups, and the reduction degree of the combined group was higher than the control group, the difference was statistically significant (P<0.05). HA, LN, PC-Ⅲ, Ⅳ-C decreased in both groups, and the reduction degree of the combined group was higher than the single group, the difference was statistically significant (P<0.05). The CD3+, CD4+, CD4+/CD8+ increased in both groups, the increaseing degree of the combined group was higher than the single group, CD8+ decreased in both groups, and the reduction degree of the combined group was higher than the single group, the difference was statistically significant (P<0.05). IL-15, IL-16, TGF-β decreased in both groups, and the reduction degree of the combined group was higher than the single group, the difference was statistically significant (P<0.05). Conclusion Zhongyao Bushen decoction combined with entecavir could effectively improve the clinical symptoms of hepatitis B patients, could regulate immune response, inflammatory response, and delay liver fibrosis. It is worthy of further clinical promotion. |
| Key words: Zhongyao Bushen decoction entecavir hepatitis B liver fibrosis inflammation immune function |
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