| 引用本文: |
李丹丹,杨玲玲,奉建芳,唐志书.无糖型半夏泻心颗粒制备工艺的研究[J].湖南中医药大学学报,2016,36(6):56-59[点击复制] |
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| 无糖型半夏泻心颗粒制备工艺的研究 |
| 李丹丹,杨玲玲,奉建芳,唐志书 |
| (陕西中医药大学, 陕西 咸阳 712046;南京朗尼医药科技有限公司, 江苏 南京 210169;南京朗尼医药科技有限公司, 江苏 南京 210169;桂林医学院, 广西 桂林 541004) |
| 摘要: |
| 目的 优选无糖型半夏泻心颗粒最佳制备工艺。方法 以黄芩苷、小檗碱含量和出膏率为指标，应用L9（34）正交设计和多指标综合评分法优选无糖型半夏泻心颗粒最佳水提取工艺；以成型性、制粒情况为指标，考察辅料、矫味剂的种类和配比。结果 最佳提取工艺为黄连用70%乙醇提取后，药渣与处方中其他6味药混合，提取3次，第一次加9倍量水，煎煮1 h，第二次加8倍量水，煎煮1 h，第三次加6倍量水，煎煮0.5 h；最佳的辅料种类和比例为浸膏粉：糊精：可溶性淀粉：甜味素=1：0.6：0.2：0.015，85%乙醇为润湿剂。结论 该工艺合理可行，适宜做无糖型半夏泻心颗粒的制备工艺。 |
| 关键词: 无糖型半夏泻心颗粒 正交实验 制备工艺 |
| DOI：10.3969/j.issn.1674-070X.2016.06.014 |
| 投稿时间：2016-02-24 |
| 基金项目: |
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| Study on Preparation Technology of Sugar-Free Banxia Xiexin Granules |
| LI Dandan,YANG Lingling,FENG Jianfang,TANG Zhishu |
| (Shaanxi University of Chinese Medicine, Xianyang, Shanxi 712046, China;Nanjing Lang-ni Pharmaceutical Co Ltd, Nanjing, Jiangsu 210023, China;Nanjing Lang-ni Pharmaceutical Co Ltd, Nanjing, Jiangsu 210023, China;Gulin Medical University, Guilin, Guangxi 541004, China) |
| Abstract: |
| Objectve To optimize preparation technology of sugar-free banxia Xiexin granules. Methods Using the content of Baicalin, berberine, and the extract yield as indexes, L9(34) orthogonal design and multi-index grading method was used to optimize the extraction process with water of sugar-free Banxia Xiexin granules. granules formability and pelletization as indexes, the types and combination ratio of accessories and corrigent were investigated. Results The best optimum extraction technology was as follows:Coptis Chinensis was extracted with 70% ethanol, residue and the other six kinds of herbs in the prescription was extracted for three times:9 times water for 2.5 h at the first time, 8 times water for 1 h at the second time, 6 times water for 0.5 h at the third time. The optimal ratio of extraction-dextrine-soluble starch-sweeteners was 1:0.6:0.2:0.015, the wetting agent was 85% ethanol. Conclusion The process is reasonable and feasible, and it is suitable for the preparation process of sugar-free Banxia Xiexin granules. |
| Key words: sugar-free Banxia Xiexin granules orthogonal experiment preparation technology |
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